技術特征：

1.一種組合物(wu)，其(qi)包括：

2.根據權利(li)要(yao)求1所述的(de)組合物，其(qi)進一(yi)步包括(c)1重(zhong)量％至20重(zhong)量％的(de)一(yi)種或多種乳化劑。

3.根據權利要求1或2所(suo)(suo)述的(de)組合物(wu)(wu)(wu)(wu)(wu)，其中所(suo)(suo)述一種(zhong)(zhong)或多(duo)種(zhong)(zhong)pufa或其衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)選自由以(yi)下組成的(de)組：亞油(you)酸(suan)(suan)(la)、γ-亞油(you)酸(suan)(suan)(gla)、二(er)(er)高-γ-亞油(you)酸(suan)(suan)(dgla)、花生(sheng)(sheng)四烯酸(suan)(suan)(aa)、腎上腺酸(suan)(suan)(ada)、ω-6二(er)(er)十二(er)(er)碳(tan)五烯酸(suan)(suan)(dpa6)、α-亞油(you)酸(suan)(suan)(ala)、亞麻油(you)酸(suan)(suan)(sda)、ω-3二(er)(er)十碳(tan)四烯酸(suan)(suan)(eta)、二(er)(er)十碳(tan)五烯酸(suan)(suan)(epa)、二(er)(er)十二(er)(er)碳(tan)五烯酸(suan)(suan)(dpa)、二(er)(er)十二(er)(er)碳(tan)六(liu)烯酸(suan)(suan)(dha)、la衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)、gla衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)、dgla衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)、aa衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)、ada衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)、dpa6衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)、ala衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)、sda衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)、eta衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)、epa衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)、dpa衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)和dha衍(yan)(yan)(yan)(yan)生(sheng)(sheng)物(wu)(wu)(wu)(wu)(wu)。

4.根(gen)據權利要求(qiu)1至3中任一項(xiang)所述(shu)的組合物，其中所述(shu)pufa衍(yan)生物包括氧化脂質(oxylipin)。

5.根據(ju)權利要求3所(suo)述(shu)的組合(he)物(wu)，其中(zhong)所(suo)述(shu)la衍生(sheng)物(wu)選自由以下(xia)組成(cheng)的組：9-氫(qing)過(guo)氧(yang)(yang)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)二(er)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(9-hpode)、13-氫(qing)過(guo)氧(yang)(yang)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)二(er)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(13-hpode)、9-羥基(ji)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)二(er)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(9-hode)、13-羥基(ji)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)二(er)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(13-hode)、9,10,13三(san)羥基(ji)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(9,10,13trihome)、9,12,13三(san)羥基(ji)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(9,12,13trihome)、9-氧(yang)(yang)代(dai)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)二(er)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(9-氧(yang)(yang)代(dai)-ode)、13-氧(yang)(yang)代(dai)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)二(er)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(13-氧(yang)(yang)代(dai)-ode)、9,10-環氧(yang)(yang)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(9,10-epome)、12,13-環氧(yang)(yang)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(12,13-epome)、9,10-二(er)羥基(ji)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(9,10-dihome)和12,13-二(er)羥基(ji)-十(shi)(shi)八(ba)(ba)(ba)碳(tan)(tan)烯(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(12,13-dihome)。

6.根(gen)據權利要求3所(suo)述的組合物，其中所(suo)述gla衍生物選(xuan)自由以下組成的組：6-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八碳(tan)三烯酸(suan)(6-hotre或(huo)(huo)(huo)6-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-gla)、7-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八碳(tan)三烯酸(suan)(7-hotre或(huo)(huo)(huo)7-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-gla)、9-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八碳(tan)三烯酸(suan)(9-hotre或(huo)(huo)(huo)9-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-gla)、10-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八碳(tan)三烯酸(suan)(10-hotre或(huo)(huo)(huo)10-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-gla)、12-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八碳(tan)三烯酸(suan)(12-hotre或(huo)(huo)(huo)12-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-gla)、13-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八碳(tan)三烯酸(suan)(13-hotre或(huo)(huo)(huo)13-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-gla)、6,13-二羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八碳(tan)二烯酸(suan)(6,13-dihode或(huo)(huo)(huo)6,13-二羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-gla)和(he)三羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)gla衍生物(三羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-gla)。

7.根據(ju)權(quan)利要求3所述的(de)組(zu)合(he)物，其中所述dgla衍生物選自由以下組(zu)成(cheng)的(de)組(zu)：前(qian)列(lie)腺(xian)素(su)d1(pgd1)、前(qian)列(lie)腺(xian)素(su)e1(pge1)、15-羥(qian)(qian)基(ji)(ji)-pge1、19-羥(qian)(qian)基(ji)(ji)-pge1、13,14-二(er)(er)羥(qian)(qian)基(ji)(ji)-pge1、13,14-二(er)(er)羥(qian)(qian)基(ji)(ji)-15-酮-pge1、前(qian)列(lie)腺(xian)素(su)f1α(pgf1α)、6-酮-pgf1α、15-酮-pgf1α、13,14-二(er)(er)羥(qian)(qian)基(ji)(ji)-pgf1α、15,19-二(er)(er)羥(qian)(qian)基(ji)(ji)-pgf1α、13,14-二(er)(er)羥(qian)(qian)基(ji)(ji)-15-酮pgf1α、前(qian)列(lie)環素(su)i1(前(qian)列(lie)腺(xian)素(su)i1或pgi1)、血栓素(su)a1(txa1)、血栓素(su)b1(txb1)、白三(san)(san)(san)烯(xi)(xi)(xi)(xi)b3(ltb3)、白三(san)(san)(san)烯(xi)(xi)(xi)(xi)c3(ltc3)、白三(san)(san)(san)烯(xi)(xi)(xi)(xi)d3(ltd3)、白三(san)(san)(san)烯(xi)(xi)(xi)(xi)e3(lte3)、5-氫過(guo)氧(yang)(yang)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)三(san)(san)(san)烯(xi)(xi)(xi)(xi)酸(suan)(5-hpetre)、8-氫過(guo)氧(yang)(yang)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)三(san)(san)(san)烯(xi)(xi)(xi)(xi)酸(suan)(8-hpetre)、12-氫過(guo)氧(yang)(yang)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)三(san)(san)(san)烯(xi)(xi)(xi)(xi)酸(suan)(12-hpetre)、15-氫過(guo)氧(yang)(yang)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)三(san)(san)(san)烯(xi)(xi)(xi)(xi)酸(suan)(15-hpetre)、5-羥(qian)(qian)基(ji)(ji)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)三(san)(san)(san)烯(xi)(xi)(xi)(xi)酸(suan)(5-hetre)、8-羥(qian)(qian)基(ji)(ji)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)三(san)(san)(san)烯(xi)(xi)(xi)(xi)酸(suan)(8-hetre)、12-羥(qian)(qian)基(ji)(ji)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)三(san)(san)(san)烯(xi)(xi)(xi)(xi)酸(suan)(12-hetre)、15-羥(qian)(qian)基(ji)(ji)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)三(san)(san)(san)烯(xi)(xi)(xi)(xi)酸(suan)(15-hetre)、8,9-環氧(yang)(yang)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)二(er)(er)烯(xi)(xi)(xi)(xi)酸(suan)(8,9-epede)、11,12-環氧(yang)(yang)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)二(er)(er)烯(xi)(xi)(xi)(xi)酸(suan)(11,12-epede)、14,15-環氧(yang)(yang)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)二(er)(er)烯(xi)(xi)(xi)(xi)酸(suan)(14,15-epede)、8,9-二(er)(er)羥(qian)(qian)基(ji)(ji)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)二(er)(er)烯(xi)(xi)(xi)(xi)酸(suan)(8,9-dihede)、11,12-二(er)(er)羥(qian)(qian)基(ji)(ji)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)二(er)(er)烯(xi)(xi)(xi)(xi)酸(suan)(11,12-dihede)和14,15-二(er)(er)羥(qian)(qian)基(ji)(ji)-二(er)(er)十(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)二(er)(er)烯(xi)(xi)(xi)(xi)酸(suan)(14,15-dihede)。

8.根據權(quan)利要(yao)求3所述(shu)的(de)組(zu)合(he)物(wu)，其中所述(shu)aa衍生(sheng)物(wu)選自(zi)由以下組(zu)成的(de)組(zu)：6-酮-前(qian)(qian)(qian)列腺(xian)素(su)(su)f1α(6k-pgf1a)、血栓素(su)(su)b2(txb2)、11-脫(tuo)(tuo)氫(qing)(qing)-血栓素(su)(su)b2(11-dtxb2)、前(qian)(qian)(qian)列腺(xian)素(su)(su)f2α(pgf2a)、前(qian)(qian)(qian)列腺(xian)素(su)(su)e2(pge2)、前(qian)(qian)(qian)列腺(xian)素(su)(su)a2(pga2)、前(qian)(qian)(qian)列腺(xian)素(su)(su)d2(pgd2)、2,3-二(er)(er)(er)(er)(er)(er)(er)(er)(er)失(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)11β-前(qian)(qian)(qian)列腺(xian)素(su)(su)f2α(2,3-二(er)(er)(er)(er)(er)(er)(er)(er)(er)失(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)11bpgf2a)、前(qian)(qian)(qian)列腺(xian)素(su)(su)j2(pgj2)、15-脫(tuo)(tuo)氧(yang)(yang)(yang)-δ-12,14-前(qian)(qian)(qian)列腺(xian)素(su)(su)j2(15d-pgj2)、白(bai)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)b4(ltb4)、20-羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-白(bai)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)b4(20-oh-ltb4)、白(bai)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)c4(ltc4)、白(bai)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)d4(ltd4)、白(bai)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)e4(lte4)、5-氫(qing)(qing)過氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(5-hpete)、8-氫(qing)(qing)過氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8-hpete)、9-氫(qing)(qing)過氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(9-hpete)、11-氫(qing)(qing)過氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(11-hpete)、12-氫(qing)(qing)過氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(12-hpete)、15-氫(qing)(qing)過氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(15-hpete)、5-羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(5-hete)、8-羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8-hete)、9-羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(9-hete)、11-羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(11-hete)、12-羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(12-hete)、15-羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(15-hete)、18-羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(18-hete)、19-羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(19-hete)、20-羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(20-hete)、5-氧(yang)(yang)(yang)代(dai)(dai)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(5-氧(yang)(yang)(yang)代(dai)(dai)-ete)、8-氧(yang)(yang)(yang)代(dai)(dai)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8-氧(yang)(yang)(yang)代(dai)(dai)-ete)、11-氧(yang)(yang)(yang)代(dai)(dai)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(11-氧(yang)(yang)(yang)代(dai)(dai)-ete)、12-氧(yang)(yang)(yang)代(dai)(dai)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(12-氧(yang)(yang)(yang)代(dai)(dai)-ete)、15-氧(yang)(yang)(yang)代(dai)(dai)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(15-氧(yang)(yang)(yang)代(dai)(dai)-ete)、脂氧(yang)(yang)(yang)素(su)(su)a4(lxa4)、脂氧(yang)(yang)(yang)素(su)(su)a5(lxa5)、肝氧(yang)(yang)(yang)蛋(dan)白(bai)a3(hepoxilin?a3，hxa3)、肝氧(yang)(yang)(yang)蛋(dan)白(bai)b3(hepoxilin?b3，hxb3)、三(san)(san)(san)(san)(san)氧(yang)(yang)(yang)蛋(dan)白(bai)a3(trioxilin?a3，trxa3)、三(san)(san)(san)(san)(san)氧(yang)(yang)(yang)蛋(dan)白(bai)b3(trioxilin?b3，trxb3)、eoxin?a4(exa4)、eoxin?c4(exc4)、eoxin?d4(exd4)、eoxin?e4(exe4)、5,6-環氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(5,6-epetre或(huo)(huo)5,6-eet)、8,9-環氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8,9-epetre或(huo)(huo)8,9-eet)、11,12-環氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(11,12-epetre或(huo)(huo)11,12-eet)、14,15-環氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(14,15-epetre或(huo)(huo)14,15-eet)、5,12-二(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(5,12-dihete)、5,6-二(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(5,6-dihetre或(huo)(huo)5,6-dihet)、8,9-二(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8,9-dihetre或(huo)(huo)8,9-dihet)、11,12-二(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(11,12-dihetre或(huo)(huo)11,12-dihet)、14,15-二(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(14,15-dihetre或(huo)(huo)14,15-dihet)和12-羥(qian)(qian)(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)十(shi)(shi)(shi)(shi)(shi)(shi)七碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)(san)(san)(san)(san)烯(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(12-hhtre)。

9.根據權(quan)利要求3所(suo)述的(de)組(zu)合物(wu)，其中所(suo)述ada衍生物(wu)選自由以(yi)下組(zu)成的(de)組(zu)：二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-前列(lie)腺(xian)素(su)(su)(su)(su)(su)e2(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-pge2)、二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-前列(lie)腺(xian)素(su)(su)(su)(su)(su)d2(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-pgd2)、二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-前列(lie)腺(xian)素(su)(su)(su)(su)(su)f2α(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-pgf2α)、二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-前列(lie)環(huan)素(su)(su)(su)(su)(su)i2(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-前列(lie)腺(xian)素(su)(su)(su)(su)(su)i2或二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-pgi2)、二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-血栓(shuan)素(su)(su)(su)(su)(su)a2(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-txa2)、二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-血栓(shuan)素(su)(su)(su)(su)(su)b2(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-txb2)、7-氫(qing)過(guo)(guo)氧(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-7-hpete)、10-氫(qing)過(guo)(guo)氧(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-10-hpete)、11-氫(qing)過(guo)(guo)氧(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-11-hpete)、13-氫(qing)過(guo)(guo)氧(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-13-hpete)、14-氫(qing)過(guo)(guo)氧(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-14-hpete)、17-氫(qing)過(guo)(guo)氧(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-17-hpete)、7-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-7-hete)、10-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-10-hete)、11-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-11-hete)、13-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-13-hete)、14-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-14-hete)、17-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-17-hete)、7,11-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-7,11-dihete)、7,14-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-7,14-dihete)、7,17-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-7,17-dihete)、10,17-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-10,17-dihete)、11,17-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-11,17-dihete)、13,15-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-13,15-dihete)、13,17-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-13,17-dihete)、16,17-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-16,17-dihete)、7,8-環(huan)氧(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-7,8-epetre)、10,11-環(huan)氧(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-10,11-epetre)、13,14-環(huan)氧(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-13,14-epetre)、16,17-環(huan)氧(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-16,17-epetre)、7,8-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-7,8-dihetre)、10,11-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-10,11-dihetre)、13,14-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-13,14-dihetre)、16,17-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-16,17-dihetre)、7,16,17-三(san)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)高(gao)(gao)(gao)(gao)(gao)(gao)-7,16,17-三(san)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-etre)和14-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-7,10,12-十(shi)(shi)(shi)(shi)(shi)(shi)九碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)(tan)三(san)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(14-hntre)。

10.根據權利要求(qiu)3所(suo)述的組合物，其中所(suo)述dpa6衍生(sheng)物選自由以(yi)下組成(cheng)的組：7-氫(qing)(qing)過(guo)氧(yang)(yang)-dpa6、8-氫(qing)(qing)過(guo)氧(yang)(yang)-dpa6、10-氫(qing)(qing)過(guo)氧(yang)(yang)-dpa6、11-氫(qing)(qing)過(guo)氧(yang)(yang)-dpa6、13-氫(qing)(qing)過(guo)氧(yang)(yang)-dpa6、14-氫(qing)(qing)過(guo)氧(yang)(yang)-dpa6、17-氫(qing)(qing)過(guo)氧(yang)(yang)-dpa6、7-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、8-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、10-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、11-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、13-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、14-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、17-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、4,5-二(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、7,14-二(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、7,17-二(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、8,14-二(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、10,17-二(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、13,17-二(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、16,17-二(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、4,5,17-三(san)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6、7,16,17-三(san)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6和10,13,17-三(san)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)-dpa6。

11.根(gen)據權利要求3所(suo)述的(de)組(zu)合物(wu)，其中所(suo)述ala衍生物(wu)選自(zi)由以下(xia)組(zu)成的(de)組(zu)：9-氫(qing)過(guo)氧(yang)(yang)(yang)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)三(san)烯(xi)(xi)酸(suan)(9-hpotre)、13-氫(qing)過(guo)氧(yang)(yang)(yang)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)三(san)烯(xi)(xi)酸(suan)(13-hpotre)、9-羥(qian)基(ji)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)三(san)烯(xi)(xi)酸(suan)(9-hotre)、13-羥(qian)基(ji)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)三(san)烯(xi)(xi)酸(suan)(13-hotre)、9,16-二(er)(er)(er)(er)羥(qian)基(ji)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)三(san)烯(xi)(xi)酸(suan)(9,16-dihotre)、9-氧(yang)(yang)(yang)代(dai)(dai)(dai)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)三(san)烯(xi)(xi)酸(suan)(9-氧(yang)(yang)(yang)代(dai)(dai)(dai)-otre)、13-氧(yang)(yang)(yang)代(dai)(dai)(dai)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)三(san)烯(xi)(xi)酸(suan)(13-氧(yang)(yang)(yang)代(dai)(dai)(dai)-otre)、9,10-環氧(yang)(yang)(yang)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)二(er)(er)(er)(er)烯(xi)(xi)酸(suan)(9,10-epode)、12,13-環氧(yang)(yang)(yang)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)二(er)(er)(er)(er)烯(xi)(xi)酸(suan)(12,13-epode)、15,16-環氧(yang)(yang)(yang)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)二(er)(er)(er)(er)烯(xi)(xi)酸(suan)(15,16-epode)、9,10-二(er)(er)(er)(er)羥(qian)基(ji)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)二(er)(er)(er)(er)烯(xi)(xi)酸(suan)(9,10-dihode)、12,13-二(er)(er)(er)(er)羥(qian)基(ji)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)二(er)(er)(er)(er)烯(xi)(xi)酸(suan)(12,13-dihode)和15,16-二(er)(er)(er)(er)羥(qian)基(ji)-八(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)二(er)(er)(er)(er)烯(xi)(xi)酸(suan)(15,16-dihode)。

12.根據權(quan)利(li)要(yao)求3所述的組(zu)合(he)物(wu)，其中所述sda衍生物(wu)選自由以下組(zu)成的組(zu)：6-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(6-hpote或(huo)(huo)(huo)(huo)6-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-sda)、7-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(7-hpote或(huo)(huo)(huo)(huo)7-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-sda)、9-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(9-hpote或(huo)(huo)(huo)(huo)9-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-sda)、10-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(10-hpote或(huo)(huo)(huo)(huo)10-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-sda)、12-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(12-hpote或(huo)(huo)(huo)(huo)12-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-sda)、13-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(13-hpote或(huo)(huo)(huo)(huo)13-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-sda)、15-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(15-hpote或(huo)(huo)(huo)(huo)15-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-sda)、16-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(16-hpote或(huo)(huo)(huo)(huo)16-氫(qing)(qing)(qing)(qing)過(guo)(guo)(guo)氧(yang)(yang)-sda)、6-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(6-hote或(huo)(huo)(huo)(huo)6-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、7-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(7-hote或(huo)(huo)(huo)(huo)7-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、9-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(9-hote或(huo)(huo)(huo)(huo)9-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、10-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(10-hote或(huo)(huo)(huo)(huo)10-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、12-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(12-hote或(huo)(huo)(huo)(huo)12-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、13-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(13-hote或(huo)(huo)(huo)(huo)13-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、15-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(15-hote或(huo)(huo)(huo)(huo)15-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、16-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)四(si)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(16-hote或(huo)(huo)(huo)(huo)16-羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、6,13-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-十(shi)(shi)八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)三(san)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(6,13-dihotre或(huo)(huo)(huo)(huo)6,13-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、6,16-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-十(shi)(shi)八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)三(san)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(6,16-dihotre或(huo)(huo)(huo)(huo)6,16-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、6,7-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-十(shi)(shi)八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)二(er)(er)(er)(er)(er)(er)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(6,7-dihode或(huo)(huo)(huo)(huo)6,7-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、9,10-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-十(shi)(shi)八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)二(er)(er)(er)(er)(er)(er)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(9,10-dihode或(huo)(huo)(huo)(huo)9,10-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、12,13-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-十(shi)(shi)八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)二(er)(er)(er)(er)(er)(er)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(12,13-dihode或(huo)(huo)(huo)(huo)12,13-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)、15,16-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-十(shi)(shi)八(ba)(ba)(ba)(ba)(ba)碳(tan)(tan)(tan)二(er)(er)(er)(er)(er)(er)烯(xi)(xi)(xi)(xi)(xi)酸(suan)(15,16-dihode或(huo)(huo)(huo)(huo)15,16-二(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)以及在sda的碳(tan)(tan)(tan)c6、c7、c9、c10、c12、c13、c15或(huo)(huo)(huo)(huo)c16中的任意三(san)個位置處攜帶羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)的三(san)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda(三(san)羥(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)-sda)。

13.根(gen)據權利要求3所(suo)述的(de)組合物(wu)，其中所(suo)述eta衍生(sheng)物(wu)選自(zi)由以下組成的(de)組：δ17,18前(qian)列(lie)(lie)腺素(su)d1(δ17,18pgd1或(huo)(huo)(huo)(huo)ω-3pgd1)、δ17,18前(qian)列(lie)(lie)腺素(su)e1(δ17,18pge1或(huo)(huo)(huo)(huo)ω-3pge1)和δ17,18前(qian)列(lie)(lie)腺素(su)f1α(δ17,18pgf1α或(huo)(huo)(huo)(huo)ω-3pgf1α)、δ17,18前(qian)列(lie)(lie)環(huan)素(su)i1(δ17,18pgi1或(huo)(huo)(huo)(huo)ω-3pge1)、δ17,18?12-氫過氧(yang)(yang)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)四(si)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ17,18?12-hpete或(huo)(huo)(huo)(huo)ω-3?12-hpete)、δ17,18?15-氫過氧(yang)(yang)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)四(si)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ17,18?15-hpete或(huo)(huo)(huo)(huo)ω-3?15-hpete)、δ16,17?18-氫過氧(yang)(yang)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)四(si)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ16,17?18-hpete)、δ17,18?12-羥(qian)(qian)(qian)基(ji)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)四(si)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ17,18?12-hete或(huo)(huo)(huo)(huo)ω-3?12-hete)、δ17,18?15-羥(qian)(qian)(qian)基(ji)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)四(si)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ17,18?15-hete或(huo)(huo)(huo)(huo)ω-3?15-hete)、δ16,17?18-羥(qian)(qian)(qian)基(ji)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)四(si)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ16,17?18-hete)、δ17,18?19-羥(qian)(qian)(qian)基(ji)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)四(si)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ17,18?19-hete或(huo)(huo)(huo)(huo)ω-3?19-hete)、δ17,18?20-羥(qian)(qian)(qian)基(ji)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)四(si)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ17,18?20-hete或(huo)(huo)(huo)(huo)ω-3?20-hete)、δ17,18?11,12環(huan)氧(yang)(yang)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)三(san)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ17,18?11,12-epetre或(huo)(huo)(huo)(huo)ω-311,12-epetre)、δ17,18?14,15環(huan)氧(yang)(yang)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)三(san)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ17,18?14,15-epetre或(huo)(huo)(huo)(huo)ω-3?14,15-epetre)和17,18環(huan)氧(yang)(yang)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)三(san)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(17,18-epetre)、δ17,18?11,12二(er)(er)羥(qian)(qian)(qian)基(ji)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)三(san)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ17,18?11,12-dihetre或(huo)(huo)(huo)(huo)ω-3?11,12-dihetre)、δ17,18?14,15二(er)(er)羥(qian)(qian)(qian)基(ji)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)三(san)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(δ17,18?14,15-dihetre或(huo)(huo)(huo)(huo)ω-3?14,15-dihetre)和17,18二(er)(er)羥(qian)(qian)(qian)基(ji)-二(er)(er)十(shi)(shi)碳(tan)(tan)(tan)三(san)烯酸(suan)(suan)(suan)(suan)(suan)(suan)(17,18-dihetre)。

14.根據(ju)權利要(yao)求3所述的組合物(wu)(wu)，其(qi)中所述epa衍生物(wu)(wu)選自由以下組成的組：6-酮-前(qian)(qian)(qian)列(lie)腺(xian)素(su)f2α(6k-pgf2a)、血栓素(su)b3(txb3)、11-脫氫(qing)-血栓素(su)b3(11-dtxb3)、前(qian)(qian)(qian)列(lie)腺(xian)素(su)f3α(pgf3a)、前(qian)(qian)(qian)列(lie)腺(xian)素(su)e3(pge3)、前(qian)(qian)(qian)列(lie)腺(xian)素(su)a3(pga3)、前(qian)(qian)(qian)列(lie)腺(xian)素(su)d3(pgd3)、2,3-二(er)(er)(er)(er)(er)(er)(er)失碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)11β-前(qian)(qian)(qian)列(lie)腺(xian)素(su)f3α(2,3-二(er)(er)(er)(er)(er)(er)(er)失碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)11bpgf3a)、前(qian)(qian)(qian)列(lie)腺(xian)素(su)j3(pgj3)、15-脫氧(yang)(yang)(yang)(yang)(yang)(yang)-δ-12,14-前(qian)(qian)(qian)列(lie)腺(xian)素(su)j3(15d-pgj3)、白三烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)b5(ltb5)、20-羥(qian)(qian)基(ji)(ji)(ji)(ji)-白三烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)b5(20-oh-ltb5)、白三烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)c5(ltc5)、白三烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)d5(ltd5)、白三烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)e5(lte5)、5-氫(qing)過(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(5-hpepe)、8-氫(qing)過(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8-hpepe)、9-氫(qing)過(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(9-hpepe)、11-氫(qing)過(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(11-hpepe)、12-氫(qing)過(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(12-hpepe)、15-氫(qing)過(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(15-hpepe)、18-氫(qing)過(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(18-hpepe)、5-羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(5-hepe)、8-羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8-hepe)、9-羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(9-hepe)、11-羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(11-hepe)、12-羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(12-hepe)、15-羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(15-hepe)、18-羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(18-hepe)、19-羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(19-hepe)、20-羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(20-hepe)、5-氧(yang)(yang)(yang)(yang)(yang)(yang)代-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(5-氧(yang)(yang)(yang)(yang)(yang)(yang)代-epe)、12-氧(yang)(yang)(yang)(yang)(yang)(yang)代-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(12-氧(yang)(yang)(yang)(yang)(yang)(yang)代-epe)、15-氧(yang)(yang)(yang)(yang)(yang)(yang)代-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)(wu)(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(15-氧(yang)(yang)(yang)(yang)(yang)(yang)代-epe)、5,6-環(huan)(huan)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(5,6-epete)、8,9-環(huan)(huan)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8,9-epete)、11,12-環(huan)(huan)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(11,12-epete)、14,15-環(huan)(huan)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(14,15-epete)、5,6-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(5,6-dihete)、8,9-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8,9-dihete)、11,12-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(11,12-dihete)、14,15-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(14,15-dihete)、17,18-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)基(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(17,18-dihete)、17,18-環(huan)(huan)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)四(si)(si)(si)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(17,18-epete)、脂(zhi)氧(yang)(yang)(yang)(yang)(yang)(yang)素(su)a5(lxa5)、脂(zhi)氧(yang)(yang)(yang)(yang)(yang)(yang)素(su)b5(lxb5)、15-epi-脂(zhi)氧(yang)(yang)(yang)(yang)(yang)(yang)素(su)a4、消退(tui)(tui)素(su)e1(rve1)、消退(tui)(tui)素(su)e2(rve2)、消退(tui)(tui)素(su)e3(rve3)和消退(tui)(tui)素(su)e4(rve4)。

15.根據權利(li)要(yao)求3所(suo)述的組(zu)合物(wu)(wu)，其(qi)中所(suo)述dpa衍生物(wu)(wu)選自由以下組(zu)成的組(zu)：7-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(7-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-dpa)、10-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(10-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-dpa)、11-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(11-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-dpa)、13-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(13-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-dpa)、14-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(14-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-dpa)、16-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(16-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-dpa)、17-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(17-氫(qing)(qing)過(guo)(guo)(guo)(guo)(guo)(guo)氧(yang)(yang)(yang)(yang)(yang)(yang)-dpa)、7-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(7-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、10-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(10-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、11-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(11-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、13-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(13-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、14-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(14-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、16-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(16-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、17-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(17-羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、7,17-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(7,17-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、8,14-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(8,14-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、10,17-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(10,17-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、10,20-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(10,20-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、13,20-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(13,20-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、16,17-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(16,17-二(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、13-氧(yang)(yang)(yang)(yang)(yang)(yang)代-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(13-氧(yang)(yang)(yang)(yang)(yang)(yang)代-dpa或13-efox-d5)、mar1n-3dpa、mar2n-3dpa、mar3n-3dpa、pd1n-3dpa、pd2n-3dpa、7,13,20-三(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-n-3-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(消(xiao)(xiao)退(tui)素t1或rvt1)、7,12,13-三(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-n-3-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(消(xiao)(xiao)退(tui)素t2或rvt2)、7,8,13-三(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-n-3-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(消(xiao)(xiao)退(tui)素t3或rvt3)、7,16,17-三(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-n-3-二(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(7,16,17-三(san)羥(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dpa)、rvd1n-3dpa、rvd2n-3dpa和rvd2n-3dpa。

16.根據權利要(yao)求3所述(shu)的(de)(de)組(zu)合物，其(qi)中(zhong)所述(shu)dha衍生物選自由以(yi)下(xia)組(zu)成(cheng)的(de)(de)組(zu)：4-氫(qing)(qing)(qing)過(guo)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(4-hpdohe)、7-氫(qing)(qing)(qing)過(guo)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(7-hpdohe)、8-氫(qing)(qing)(qing)過(guo)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8-hpdohe)、10-氫(qing)(qing)(qing)過(guo)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(10-hpdohe)、11-氫(qing)(qing)(qing)過(guo)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(11-hpdohe)、13-氫(qing)(qing)(qing)過(guo)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(13-hpdohe)、14-氫(qing)(qing)(qing)過(guo)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(14-hpdohe)、16-氫(qing)(qing)(qing)過(guo)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(16-hpdohe)、17-氫(qing)(qing)(qing)過(guo)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(17-hpdohe)、4-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(4-hdohe)、7-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(7-hdohe)、8-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8-hdohe)、10-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(10-hdohe)、11-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(11-hdohe)、13-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(13-hdohe)、14-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(14-hdohe)、16-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(16-hdohe)、17-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(17-hdohe)、20-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(20-hdohe)、21-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(21-hdohe)、22-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(22-hdohe)、7,14-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(7,14-dihdohe)、7,17-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(7,17-dihdohe)、8,14-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(8,14-dihdohe)、10,17-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(10,17-dihdohe)、10,20-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(10,20-dihdohe)、14,20-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(14,20-dihdohe)、14,21-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(14,21-dihdohe)、7-氧(yang)(yang)(yang)代-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(7-氧(yang)(yang)(yang)代-dohe)、4,5-環(huan)(huan)(huan)(huan)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(4,5-epdpe)、7,8-環(huan)(huan)(huan)(huan)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(7,8-epdpe)、10,11-環(huan)(huan)(huan)(huan)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(10,11-epdpe)、13,14-環(huan)(huan)(huan)(huan)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(13,14-epdpe)、16,17-環(huan)(huan)(huan)(huan)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(16,17-epdpe)、19,20-環(huan)(huan)(huan)(huan)氧(yang)(yang)(yang)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(19,20-epdpe)、4,5-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(4,5-dihdpe)、7,8-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(7,8-dihdpe)、10,11-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(10,11-dihdpe)、13,14-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(13,14-dihdpe)、16,17-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(16,17-dihdpe)、19,20-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)五(wu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(19,20-dihdpe)、4,5-環(huan)(huan)(huan)(huan)氧(yang)(yang)(yang)-17-oh-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)、(4,5-環(huan)(huan)(huan)(huan)氧(yang)(yang)(yang)-17-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dha)、7,8-環(huan)(huan)(huan)(huan)氧(yang)(yang)(yang)-17-oh-二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)十(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)(shi)二(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)(er)碳(tan)(tan)(tan)(tan)(tan)(tan)(tan)六(liu)(liu)(liu)(liu)(liu)(liu)(liu)烯(xi)(xi)(xi)(xi)(xi)(xi)(xi)(xi)酸(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(suan)(7,8-環(huan)(huan)(huan)(huan)氧(yang)(yang)(yang)-17-羥(qian)(qian)(qian)(qian)(qian)(qian)基(ji)(ji)(ji)(ji)(ji)-dha)、馬(ma)來(lai)素(su)(su)(su)(su)1(maresin?1，mar1)、馬(ma)來(lai)素(su)(su)(su)(su)2(maresin?2，mar2)、保護素(su)(su)(su)(su)1(pd1)、保護素(su)(su)(su)(su)x(pdx)、阿(a)司匹(pi)林(lin)(lin)(lin)觸(chu)發(fa)的(de)(de)pd1(at-pd1)、消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d1(rvd1)、消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d2(rvd2)、消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d3(rvd3)、消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d4(rvd4)、消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d5(rvd5)、消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d6(rvd6)、阿(a)司匹(pi)林(lin)(lin)(lin)觸(chu)發(fa)的(de)(de)消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d1(at-rvd1)、阿(a)司匹(pi)林(lin)(lin)(lin)觸(chu)發(fa)的(de)(de)消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d2(at-rvd2)、阿(a)司匹(pi)林(lin)(lin)(lin)觸(chu)發(fa)的(de)(de)消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d3(at-rvd3)、阿(a)司匹(pi)林(lin)(lin)(lin)觸(chu)發(fa)的(de)(de)消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d4(at-rvd4)、阿(a)司匹(pi)林(lin)(lin)(lin)觸(chu)發(fa)的(de)(de)消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d5(at-rvd5)和(he)阿(a)司匹(pi)林(lin)(lin)(lin)觸(chu)發(fa)的(de)(de)消(xiao)(xiao)(xiao)(xiao)(xiao)退(tui)(tui)(tui)(tui)(tui)素(su)(su)(su)(su)d6(at-rvd6)。

17.根(gen)據權利(li)要求1或(huo)2所述的組合物(wu)，其(qi)中所述一種(zhong)或(huo)多種(zhong)pufa或(huo)其(qi)衍生(sheng)物(wu)選自由以下組成的組：二十(shi)四(si)碳(tan)四(si)烯酸(suan)(tte)、二十(shi)四(si)碳(tan)五(wu)烯酸(suan)(tpa)、二十(shi)四(si)碳(tan)六烯酸(suan)(tha)、tte衍生(sheng)物(wu)、tpa衍生(sheng)物(wu)和tha衍生(sheng)物(wu)。

18.根據(ju)權利要求1或2所(suo)述(shu)的組合物，其(qi)(qi)中所(suo)述(shu)一種或多種pufa或其(qi)(qi)衍生物包括(kuo)呈(cheng)游離(li)酸形(xing)式的epa或其(qi)(qi)藥學(xue)上可接受的酯、綴合物或鹽。

19.根據(ju)權利(li)要求18所述(shu)的組合(he)物(wu)，其(qi)中所述(shu)epa是二(er)十碳(tan)五烯酸(suan)乙基酯(etepa)。

20.根據(ju)權利要求18或19所(suo)述(shu)的(de)組合物(wu)(wu)，其中所(suo)述(shu)epa或所(suo)述(shu)etepa占所(suo)述(shu)組合物(wu)(wu)中存在的(de)所(suo)有pufa的(de)至少(shao)66重(zhong)量(liang)％、75重(zhong)量(liang)％、80重(zhong)量(liang)％、90重(zhong)量(liang)％、95重(zhong)量(liang)％或96重(zhong)量(liang)％。

21.根據權利要求18或(huo)19所(suo)述的(de)組(zu)合物，其(qi)中所(suo)述組(zu)合物占所(suo)述組(zu)合物中存在的(de)所(suo)有pufa的(de)不大(da)于20重(zhong)量％，包括以下(xia)中的(de)一種或(huo)多種：

22.根據權利要求18至(zhi)21中任一項所述(shu)(shu)的組合物(wu)，其中所述(shu)(shu)組合物(wu)包(bao)括約(yue)500mg至(zhi)約(yue)1g的所述(shu)(shu)epa或所述(shu)(shu)etepa。

23.根據權(quan)利要求1至22中任(ren)一項所述的組合物，其(qi)中所述磷(lin)脂(zhi)(zhi)來源包括甘(gan)油磷(lin)脂(zhi)(zhi)、溶(rong)血磷(lin)脂(zhi)(zhi)或其(qi)混合物。

24.根據權(quan)利要求23所述(shu)的組合物，其(qi)中所述(shu)磷脂來源是(shi)卵磷脂。

25.根據權(quan)利要求24所(suo)述(shu)(shu)的(de)組合物，其中所(suo)述(shu)(shu)卵(luan)(luan)磷(lin)脂(zhi)(zhi)包括按所(suo)述(shu)(shu)卵(luan)(luan)磷(lin)脂(zhi)(zhi)的(de)重(zhong)量計至(zhi)(zhi)多(duo)40％、至(zhi)(zhi)多(duo)60％、至(zhi)(zhi)多(duo)80％、至(zhi)(zhi)多(duo)90％、至(zhi)(zhi)多(duo)95％或至(zhi)(zhi)多(duo)97％的(de)磷(lin)脂(zhi)(zhi)酰乙醇胺以及(ji)按所(suo)述(shu)(shu)卵(luan)(luan)磷(lin)脂(zhi)(zhi)的(de)重(zhong)量計不大(da)于10％、不大(da)于5％、不大(da)于4％、不大(da)于3％、不大(da)于2％或不大(da)于1％的(de)磷(lin)脂(zhi)(zhi)酰肌醇。

26.根據(ju)權利要求24所(suo)述的組(zu)合物，其(qi)中所(suo)述卵磷脂包括(kuo)：

27.根據權利要求1至(zhi)26中任(ren)一項所(suo)述(shu)的組合物(wu)，其中所(suo)述(shu)一種或多種pufa或其衍生物(wu)與所(suo)述(shu)磷(lin)脂來(lai)源的重量比的范圍為約(yue)(yue)5:1至(zhi)約(yue)(yue)1:5、約(yue)(yue)3.75:1至(zhi)約(yue)(yue)1:5或約(yue)(yue)1:1至(zhi)約(yue)(yue)1:5。

28.根據(ju)權利要求20所述(shu)的(de)組合物，其中所述(shu)epa或所述(shu)etepa與所述(shu)磷脂來(lai)源(yuan)的(de)重(zhong)量比的(de)范圍為約1:1至約1:5。

29.根據權利要求2至28中任一項(xiang)所(suo)述(shu)的組合物(wu)，其中所(suo)述(shu)一種(zhong)或多種(zhong)乳化劑包括聚山梨醇(chun)酯80、聚氧乙烯-35或兩者。

30.根(gen)據權(quan)利要(yao)求2至28中(zhong)任一項所(suo)述(shu)(shu)的組合物(wu)，其中(zhong)所(suo)述(shu)(shu)一種或(huo)多種乳化劑包括(kuo)一種或(huo)多種甘(gan)(gan)油(you)(you)衍(yan)生(sheng)(sheng)物(wu)，所(suo)述(shu)(shu)一種或(huo)多種甘(gan)(gan)油(you)(you)衍(yan)生(sheng)(sheng)物(wu)選自由(you)甘(gan)(gan)油(you)(you)三(san)酯(zhi)、甘(gan)(gan)油(you)(you)二(er)酯(zhi)和單(dan)酰甘(gan)(gan)油(you)(you)組成的組。

31.根據權利要求30所(suo)述(shu)的組(zu)合物，其中所(suo)述(shu)甘(gan)油衍生物是蓖麻油。

32.根據權利(li)要求30所述的(de)組合物，其中所述甘油(you)衍生物是(shi)富含(han)所述pufa的(de)經再酯化的(de)甘油(you)三酯(rtg)。

33.一(yi)種試劑盒，其包括(kuo)：

34.根(gen)據權利要求33所述(shu)的試(shi)劑盒，其中所述(shu)第一組(zu)(zu)合物和/或所述(shu)第二組(zu)(zu)合物進一步包括一種或多種乳(ru)化劑。

35.根據權利(li)要求33或34所述(shu)的試劑盒，其中(zhong)所述(shu)一種或多(duo)種pufa或其衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)選自(zi)由以(yi)下組成(cheng)的組：亞(ya)油(you)(you)酸(suan)(suan)(suan)(suan)(suan)(la)、γ-亞(ya)油(you)(you)酸(suan)(suan)(suan)(suan)(suan)(gla)、二(er)(er)(er)高-γ-亞(ya)油(you)(you)酸(suan)(suan)(suan)(suan)(suan)(dgla)、花生(sheng)(sheng)(sheng)(sheng)四(si)(si)烯酸(suan)(suan)(suan)(suan)(suan)(aa)、腎上腺酸(suan)(suan)(suan)(suan)(suan)(ada)、ω-6二(er)(er)(er)十(shi)(shi)(shi)二(er)(er)(er)碳(tan)五烯酸(suan)(suan)(suan)(suan)(suan)(dpa6)、α-亞(ya)油(you)(you)酸(suan)(suan)(suan)(suan)(suan)(ala)、亞(ya)麻油(you)(you)酸(suan)(suan)(suan)(suan)(suan)(sda)、ω-3二(er)(er)(er)十(shi)(shi)(shi)碳(tan)四(si)(si)烯酸(suan)(suan)(suan)(suan)(suan)(eta)、二(er)(er)(er)十(shi)(shi)(shi)碳(tan)五烯酸(suan)(suan)(suan)(suan)(suan)(epa)、二(er)(er)(er)十(shi)(shi)(shi)二(er)(er)(er)碳(tan)五烯酸(suan)(suan)(suan)(suan)(suan)(dpa)、二(er)(er)(er)十(shi)(shi)(shi)二(er)(er)(er)碳(tan)六烯酸(suan)(suan)(suan)(suan)(suan)(dha)、la衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)、gla衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)、dgla衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)、aa衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)、ada衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)、dpa6衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)、ala衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)、sda衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)、eta衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)、epa衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)、dpa衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)和dha衍(yan)(yan)生(sheng)(sheng)(sheng)(sheng)物(wu)(wu)(wu)。

36.根據權(quan)利要(yao)求(qiu)33或(huo)34所述的試劑盒，其中所述一種或(huo)多種pufa或(huo)其衍生(sheng)(sheng)物選(xuan)自(zi)由以下組成的組：二(er)十四碳(tan)(tan)四烯酸(suan)(tte)、二(er)十四碳(tan)(tan)五(wu)烯酸(suan)(tpa)、二(er)十四碳(tan)(tan)六烯酸(suan)(tha)、tte衍生(sheng)(sheng)物、tpa衍生(sheng)(sheng)物和tha衍生(sheng)(sheng)物。

37.根據權利要(yao)求33至(zhi)36中任(ren)一項所述(shu)的試劑(ji)盒(he)，其中所述(shu)pufa衍生物包(bao)括(kuo)氧化脂質(zhi)。

38.根據權利要求(qiu)33或(huo)34所(suo)述的(de)試劑盒，其中所(suo)述一種或(huo)多種pufa或(huo)其衍生(sheng)物包括呈游(you)離酸形式(shi)的(de)epa或(huo)其藥學上可(ke)接受的(de)酯(zhi)、綴合物或(huo)鹽。

39.根據權(quan)利(li)要(yao)求38所(suo)述的試(shi)劑盒，其中所(suo)述epa是二十碳五烯酸乙基酯(etepa)。

40.根據權利要求38或39所(suo)述(shu)的試劑盒，其中所(suo)述(shu)epa或所(suo)述(shu)etepa占所(suo)述(shu)第一組合物中存在的所(suo)有pufa的至少66重(zhong)量(liang)(liang)％、75重(zhong)量(liang)(liang)％、80重(zhong)量(liang)(liang)％、90重(zhong)量(liang)(liang)％、95重(zhong)量(liang)(liang)％或96重(zhong)量(liang)(liang)％。

41.根據(ju)權(quan)利要求38或39所述的(de)(de)試劑(ji)盒，其中所述第一組(zu)合物占所述第一組(zu)合物中存(cun)在的(de)(de)所有pufa的(de)(de)不大于20重量％，包括以下中的(de)(de)一種或多種：

42.根據權利(li)要求38至41中任一(yi)項所(suo)述的試(shi)劑盒，其中所(suo)述第(di)一(yi)組(zu)合物包括約500mg至約1g的所(suo)述epa或(huo)所(suo)述etepa。

43.根據權利要求33至42中任一項(xiang)所述(shu)的試劑(ji)盒，其中所述(shu)磷(lin)脂來源包(bao)括(kuo)甘油磷(lin)脂、溶(rong)血磷(lin)脂或其混合物(wu)。

44.根據權利要求43所述的試劑盒(he)，其中所述磷脂來(lai)源是卵磷脂。

45.根據權利(li)要求44所述(shu)的(de)試劑盒，其中所述(shu)卵磷脂(zhi)包括(kuo)按(an)所述(shu)卵磷脂(zhi)的(de)重量(liang)(liang)計至(zhi)(zhi)多(duo)40％、至(zhi)(zhi)多(duo)60％、至(zhi)(zhi)多(duo)80％、至(zhi)(zhi)多(duo)90％、至(zhi)(zhi)多(duo)95％或至(zhi)(zhi)多(duo)97％的(de)磷脂(zhi)酰乙(yi)醇胺以及按(an)所述(shu)卵磷脂(zhi)的(de)重量(liang)(liang)計不大于10％、不大于5％、不大于4％、不大于3％、不大于2％或不大于1％的(de)磷脂(zhi)酰肌(ji)醇。

46.根據權利要(yao)求44所述(shu)的試劑盒，其中所述(shu)卵磷脂包括：

47.根據權利(li)要(yao)求33至(zhi)46中(zhong)任一項所(suo)述的試劑盒，其中(zhong)所(suo)述一種(zhong)或(huo)(huo)多種(zhong)pufa或(huo)(huo)其衍生(sheng)物(wu)與所(suo)述磷脂(zhi)來源的重量比的范圍為(wei)約5:1至(zhi)約1:5、約3.75:1至(zhi)約1:5或(huo)(huo)約1:1至(zhi)約1:5。

48.根(gen)據權利要求(qiu)40所(suo)(suo)述的試劑盒，其中所(suo)(suo)述epa或所(suo)(suo)述etepa與(yu)所(suo)(suo)述磷脂來源的重量比的范圍為約1:1至約1:5。

49.根據權利要求34至48中任一(yi)項所述的試劑盒，其中所述一(yi)種(zhong)或(huo)多(duo)種(zhong)乳化(hua)劑包括聚山梨醇酯80、聚氧乙(yi)烯-35或(huo)兩者。

50.根據(ju)權(quan)利(li)要求34至48中(zhong)任一(yi)項所述(shu)的試(shi)劑(ji)盒，其中(zhong)所述(shu)一(yi)種(zhong)(zhong)或多種(zhong)(zhong)乳化(hua)劑(ji)包(bao)括一(yi)種(zhong)(zhong)或多種(zhong)(zhong)甘油(you)衍生物，所述(shu)一(yi)種(zhong)(zhong)或多種(zhong)(zhong)甘油(you)衍生物選自由(you)甘油(you)三酯、甘油(you)二酯和單酰(xian)甘油(you)組成(cheng)的組。

51.根據權(quan)利要求50所述的(de)試劑盒，其(qi)中(zhong)所述甘油衍生物是蓖(bi)麻油。

52.根據權利(li)要求(qiu)50所(suo)述(shu)的(de)試劑盒(he)，其中所(suo)述(shu)甘油衍生物是富含所(suo)述(shu)pufa的(de)經再酯化的(de)甘油三酯(rtg)。

53.一(yi)種淋巴釋放(fang)的二十碳五烯酸(suan)乙基(ji)酯(lr-etepa)組(zu)合物，其包(bao)括：

54.根據權利要求(qiu)53所述的lr-etepa組(zu)合(he)物，其進一步包括(c)1重(zhong)(zhong)量(liang)％至20重(zhong)(zhong)量(liang)％的一種(zhong)或(huo)多種(zhong)乳化劑(ji)。

55.根據權(quan)利要求53或(huo)54所述(shu)(shu)的lr-etepa組合物，其(qi)中所述(shu)(shu)etepa占所述(shu)(shu)組合物中存在的所有脂肪酸的至少(shao)66重量(liang)％、75重量(liang)％、80重量(liang)％、90重量(liang)％、95重量(liang)％或(huo)96重量(liang)％。

56.根據(ju)權利(li)要(yao)求53至55中(zhong)任一項所(suo)(suo)述的lr-etepa組(zu)合物，其中(zhong)所(suo)(suo)述組(zu)合物包(bao)括(kuo)約500mg至約1g的所(suo)(suo)述etepa。

57.根據權利要求53至56中任一(yi)項所述(shu)的lr-etepa組合物(wu)，其中所述(shu)磷(lin)脂來源包(bao)括甘油磷(lin)脂、溶血磷(lin)脂或(huo)其混(hun)合物(wu)。

58.根據權(quan)利(li)要求57所述的(de)lr-etepa組(zu)合物，其中所述磷脂來源是卵(luan)磷脂。

59.根(gen)據(ju)權利要求(qiu)58所(suo)述的lr-etepa組合物，其中所(suo)述卵(luan)磷(lin)脂(zhi)包(bao)括按所(suo)述卵(luan)磷(lin)脂(zhi)的重量計(ji)至(zhi)(zhi)多(duo)40％、至(zhi)(zhi)多(duo)60％、至(zhi)(zhi)多(duo)80％、至(zhi)(zhi)多(duo)90％、至(zhi)(zhi)多(duo)95％或(huo)至(zhi)(zhi)多(duo)97％的磷(lin)脂(zhi)酰(xian)乙醇(chun)胺(an)以及(ji)按所(suo)述卵(luan)磷(lin)脂(zhi)的重量計(ji)不(bu)(bu)大(da)于(yu)(yu)(yu)(yu)10％、不(bu)(bu)大(da)于(yu)(yu)(yu)(yu)5％、不(bu)(bu)大(da)于(yu)(yu)(yu)(yu)4％、不(bu)(bu)大(da)于(yu)(yu)(yu)(yu)3％、不(bu)(bu)大(da)于(yu)(yu)(yu)(yu)2％或(huo)不(bu)(bu)大(da)于(yu)(yu)(yu)(yu)1％的磷(lin)脂(zhi)酰(xian)肌(ji)醇(chun)。

60.根(gen)據權利要求58所(suo)述的lr-etepa組合物，其中所(suo)述卵磷(lin)脂包括：

61.根據權(quan)利要(yao)求53至(zhi)(zhi)60中(zhong)任一項所(suo)述(shu)(shu)的lr-etepa組(zu)合物，其中(zhong)所(suo)述(shu)(shu)etepa與所(suo)述(shu)(shu)磷脂來源的重量比(bi)的范圍為約(yue)(yue)5:1至(zhi)(zhi)約(yue)(yue)1:5、約(yue)(yue)3.75:1至(zhi)(zhi)約(yue)(yue)1:5或約(yue)(yue)1:1至(zhi)(zhi)約(yue)(yue)1:5。

62.根據權(quan)利(li)要求54至(zhi)61中任一項所述的(de)lr-etepa組合物，其中所述一種或多種乳化劑包括聚(ju)(ju)山梨醇酯80、聚(ju)(ju)氧乙(yi)烯-35或兩者。

63.根據權利要求54至(zhi)61中任(ren)一項(xiang)所述的(de)lr-etepa組(zu)合物，其中所述一種(zhong)或(huo)多種(zhong)乳化劑(ji)包括(kuo)一種(zhong)或(huo)多種(zhong)甘油衍生(sheng)(sheng)物，所述一種(zhong)或(huo)多種(zhong)甘油衍生(sheng)(sheng)物選自由(you)甘油三酯、甘油二酯和(he)單酰甘油組(zu)成的(de)組(zu)。

64.根據(ju)權利(li)要求63所述(shu)的lr-etepa組(zu)合物，其(qi)中所述(shu)甘油衍生物是蓖麻油。

65.根據權利要求(qiu)63所(suo)(suo)(suo)述(shu)的(de)(de)lr-etepa組合物，其(qi)中所(suo)(suo)(suo)述(shu)甘(gan)油衍生物是富含所(suo)(suo)(suo)述(shu)pufa的(de)(de)經再酯化的(de)(de)甘(gan)油三酯(rtg)。

66.根據權利要求53至65中任一(yi)項(xiang)所述(shu)(shu)的(de)lr-etepa組合物，其中所述(shu)(shu)etepa與所述(shu)(shu)磷(lin)脂(zhi)來源以同一(yi)劑(ji)量單位共調配或以單獨(du)的(de)劑(ji)量單位單獨(du)調配。

67.根據權利要求66所(suo)述(shu)(shu)的lr-etepa組(zu)合物(wu)，其中所(suo)述(shu)(shu)劑量單位是膠囊(nang)。

68.一種治療或預防有需要(yao)(yao)的(de)受試者的(de)疾病的(de)方法，所(suo)述(shu)方法包括向所(suo)述(shu)受試者施用(yong)治療有效量的(de)根(gen)(gen)據權利要(yao)(yao)求1至32中任(ren)一項(xiang)(xiang)所(suo)述(shu)的(de)組合物、根(gen)(gen)據權利要(yao)(yao)求33至52中任(ren)一項(xiang)(xiang)所(suo)述(shu)的(de)試劑(ji)盒或根(gen)(gen)據權利要(yao)(yao)求53至67中任(ren)一項(xiang)(xiang)所(suo)述(shu)的(de)lr-etepa組合物。

69.根據權利要求(qiu)68所述的方(fang)法，其中所述疾(ji)病是心(xin)血(xue)管疾(ji)病。

70.根(gen)據權利要(yao)求69所(suo)述的(de)方法，其中所(suo)述心(xin)(xin)(xin)(xin)血(xue)(xue)管(guan)(guan)(guan)疾(ji)病(bing)(bing)(bing)選自由以下(xia)組(zu)成的(de)組(zu)：高(gao)甘油三酯血(xue)(xue)癥、高(gao)膽固醇血(xue)(xue)癥、混(hun)合性(xing)(xing)血(xue)(xue)脂異(yi)常、冠(guan)心(xin)(xin)(xin)(xin)病(bing)(bing)(bing)、中風、動脈(mo)粥樣硬化、心(xin)(xin)(xin)(xin)律失常、高(gao)血(xue)(xue)壓、心(xin)(xin)(xin)(xin)肌(ji)梗塞(sai)、血(xue)(xue)管(guan)(guan)(guan)炎、心(xin)(xin)(xin)(xin)肌(ji)病(bing)(bing)(bing)(例(li)如，病(bing)(bing)(bing)毒(du)性(xing)(xing)心(xin)(xin)(xin)(xin)肌(ji)病(bing)(bing)(bing)，包含與covid-19相(xiang)關的(de)病(bing)(bing)(bing)毒(du)性(xing)(xing)心(xin)(xin)(xin)(xin)肌(ji)病(bing)(bing)(bing))、心(xin)(xin)(xin)(xin)包炎、充血(xue)(xue)性(xing)(xing)心(xin)(xin)(xin)(xin)力衰(shuai)竭、心(xin)(xin)(xin)(xin)肌(ji)壞死(si)、血(xue)(xue)管(guan)(guan)(guan)缺血(xue)(xue)、心(xin)(xin)(xin)(xin)肺系統(tong)外血(xue)(xue)管(guan)(guan)(guan)疾(ji)病(bing)(bing)(bing)、血(xue)(xue)栓(shuan)性(xing)(xing)疾(ji)病(bing)(bing)(bing)、心(xin)(xin)(xin)(xin)肌(ji)梗塞(sai)后心(xin)(xin)(xin)(xin)臟重構、巨細胞(bao)動脈(mo)炎、結節性(xing)(xing)多動脈(mo)炎、冷球蛋白血(xue)(xue)癥、發作性(xing)(xing)小血(xue)(xue)管(guan)(guan)(guan)缺血(xue)(xue)(雷諾(nuo)氏(shi)病(bing)(bing)(bing)(raynaud's?disease))、深靜脈(mo)血(xue)(xue)栓(shuan)形(xing)成、彌散性(xing)(xing)血(xue)(xue)管(guan)(guan)(guan)內(nei)凝(ning)血(xue)(xue)和(he)勃起功能障礙。

71.根(gen)據權利要求69或70所述的(de)方法，其(qi)中所述受試者的(de)空腹基線(xian)甘油三酯(zhi)水(shui)平為(wei)約(yue)135mg/dl至約(yue)500mg/dl。

72.根據權利要求69至71中(zhong)(zhong)任一(yi)項所述的(de)(de)方法，其(qi)中(zhong)(zhong)所述受(shou)試者具有(you)以(yi)(yi)下(xia)中(zhong)(zhong)的(de)(de)一(yi)項或多項：約(yue)(yue)200mg/dl至約(yue)(yue)300mg/dl的(de)(de)基(ji)線非高(gao)密(mi)度脂(zhi)蛋白(bai)(bai)膽(dan)固醇(hdl-c)值；約(yue)(yue)250mg/dl至約(yue)(yue)300mg/dl的(de)(de)基(ji)線總膽(dan)固醇(tc)值；約(yue)(yue)140mg/dl至約(yue)(yue)200mg/dl的(de)(de)基(ji)線極(ji)低(di)(di)密(mi)度脂(zhi)蛋白(bai)(bai)膽(dan)固醇(vldl-c)值；約(yue)(yue)10mg/dl至約(yue)(yue)30mg/dl的(de)(de)基(ji)線hdl-c值；約(yue)(yue)40mg/dl至約(yue)(yue)100mg/dl的(de)(de)基(ji)線低(di)(di)密(mi)度脂(zhi)蛋白(bai)(bai)膽(dan)固醇(ldl-c)值；以(yi)(yi)及(ji)約(yue)(yue)2mg/dl或更(geng)低(di)(di)的(de)(de)基(ji)線高(gao)敏感c反(fan)應蛋白(bai)(bai)(hscrp)水平。

73.根據權利(li)要求69至(zhi)72中(zhong)任一項所述的方(fang)法(fa)，其中(zhong)所述受(shou)試者正在進行穩定的他汀類療法(fa)。

74.根據(ju)權利要求(qiu)73所(suo)(suo)述的方法(fa)，其中所(suo)(suo)述穩定的他汀(ting)類療法(fa)包括他汀(ting)類以及任選地依折麥布(ezetimibe)。

75.根據權(quan)利(li)要求74所(suo)述的方法，其中(zhong)所(suo)述他汀(ting)(ting)類(lei)選(xuan)自由以下組成的組：阿托伐(fa)他汀(ting)(ting)(atorvastatin)、氟伐(fa)他汀(ting)(ting)(fluvastatin)、洛伐(fa)他汀(ting)(ting)(lovastatin)、匹伐(fa)他汀(ting)(ting)(pitavastatin)、普伐(fa)他汀(ting)(ting)(pravastatin)、瑞(rui)舒伐(fa)他汀(ting)(ting)(rosuvastatin)和辛伐(fa)他汀(ting)(ting)(simvastatin)。

76.根據權(quan)利要求68所(suo)述(shu)的方法，其中(zhong)所(suo)述(shu)疾(ji)病是肺部疾(ji)病。

77.根據權(quan)利要(yao)求76所述(shu)的(de)方法，其中所述(shu)肺(fei)(fei)部(bu)疾病(bing)(bing)選自由(you)以下組成的(de)組：社區(qu)獲得性(xing)(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)炎(yan)(yan)、covid-19肺(fei)(fei)炎(yan)(yan)、全身性(xing)(xing)(xing)(xing)(xing)(xing)炎(yan)(yan)癥反(fan)應綜(zong)合征(zheng)(sirs)、敗血癥、sirs、急性(xing)(xing)(xing)(xing)(xing)(xing)呼吸窘(jiong)迫綜(zong)合征(zheng)(ards)、肺(fei)(fei)栓塞(sai)、彌漫性(xing)(xing)(xing)(xing)(xing)(xing)間(jian)(jian)質(zhi)性(xing)(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)炎(yan)(yan)、放射(she)性(xing)(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)炎(yan)(yan)、胸膜炎(yan)(yan)、急性(xing)(xing)(xing)(xing)(xing)(xing)嗜(shi)酸性(xing)(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)炎(yan)(yan)、慢性(xing)(xing)(xing)(xing)(xing)(xing)嗜(shi)酸性(xing)(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)炎(yan)(yan)、呂弗(fu)勒綜(zong)合征(zheng)(loffler?syndrome)、結節病(bing)(bing)、間(jian)(jian)質(zhi)性(xing)(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)病(bing)(bing)、慢性(xing)(xing)(xing)(xing)(xing)(xing)阻塞(sai)性(xing)(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)部(bu)疾病(bing)(bing)(copd)、反(fan)應性(xing)(xing)(xing)(xing)(xing)(xing)氣(qi)道疾病(bing)(bing)、哮(xiao)喘(chuan)、支(zhi)氣(qi)管擴張、細支(zhi)氣(qi)管炎(yan)(yan)、囊性(xing)(xing)(xing)(xing)(xing)(xing)纖維化、支(zhi)氣(qi)管類(lei)癌、肺(fei)(fei)動脈高壓、肺(fei)(fei)血管炎(yan)(yan)、顯微多(duo)血管炎(yan)(yan)、肉芽腫性(xing)(xing)(xing)(xing)(xing)(xing)多(duo)血管炎(yan)(yan)(韋(wei)格(ge)納氏病(bing)(bing)(wegener's?disease))、嗜(shi)酸性(xing)(xing)(xing)(xing)(xing)(xing)肉芽腫性(xing)(xing)(xing)(xing)(xing)(xing)多(duo)血管炎(yan)(yan)(查爾格(ge)-施(shi)特勞斯綜(zong)合征(zheng)(churg-strauss))、鼻(bi)咽炎(yan)(yan)、古德帕斯丘氏綜(zong)合征(zheng)(goodpasture's?syndrome)、冷球蛋白血癥、系統(tong)性(xing)(xing)(xing)(xing)(xing)(xing)紅斑狼瘡(sle)、系統(tong)性(xing)(xing)(xing)(xing)(xing)(xing)硬化癥和(he)抗磷脂綜(zong)合征(zheng)。

78.根(gen)據權利要求68所(suo)述的(de)方法，其中所(suo)述疾病是神(shen)經(jing)系統疾病。

79.根據權利要(yao)求78所(suo)述(shu)的(de)方(fang)法，其中(zhong)所(suo)述(shu)神經(jing)系(xi)統疾病(bing)(bing)選自由以下組(zu)成的(de)組(zu)：亨(heng)廷(ting)頓氏病(bing)(bing)(huntington's?disease)、睡眠障(zhang)礙、癡(chi)呆(dai)、精(jing)(jing)神病(bing)(bing)、焦(jiao)慮癥(zheng)、難(nan)治性(xing)(xing)抑郁癥(zheng)、神經(jing)性(xing)(xing)疼(teng)痛、精(jing)(jing)神分裂癥(zheng)、雙相情感障(zhang)礙、閱讀(du)障(zhang)礙、運(yun)動障(zhang)礙、注(zhu)意力缺(que)(que)陷(xian)(xian)多動障(zhang)礙(adhd)、癲癇、自閉癥(zheng)、阿爾茨海默氏病(bing)(bing)(alzheimer's?disease)、帕金森(sen)氏病(bing)(bing)(parkinson'sdisease)、老年性(xing)(xing)癡(chi)呆(dai)、多發性(xing)(xing)硬(ying)化(hua)癥(zheng)、糖尿(niao)病(bing)(bing)誘導的(de)神經(jing)病(bing)(bing)變(bian)、黃斑變(bian)性(xing)(xing)、早產兒(er)視網(wang)膜病(bing)(bing)變(bian)、肌(ji)萎縮(suo)性(xing)(xing)側索硬(ying)化(hua)癥(zheng)(als)、視網(wang)膜色(se)素變(bian)性(xing)(xing)癥(zheng)、腦(nao)癱、肌(ji)肉萎縮(suo)癥(zheng)、神經(jing)系(xi)統癌癥(zheng)、囊性(xing)(xing)纖維化(hua)和(he)神經(jing)管缺(que)(que)陷(xian)(xian)。

80.根據權利要(yao)求68所述的方法，其(qi)中所述疾病是癌癥。

81.根據權利要求(qiu)80所述(shu)(shu)的(de)方法，其中所述(shu)(shu)癌癥是(shi)選(xuan)自由以下組(zu)成的(de)組(zu)的(de)血(xue)(xue)(xue)(xue)(xue)液系(xi)統惡性病(bing)：單克隆b細(xi)(xi)胞(bao)淋巴(ba)(ba)細(xi)(xi)胞(bao)增多(duo)癥、多(duo)發性骨(gu)(gu)髓(sui)瘤、髓(sui)系(xi)贅(zhui)生物、骨(gu)(gu)髓(sui)增生異常綜(zong)合征(zheng)(mds)、骨(gu)(gu)髓(sui)增殖/骨(gu)(gu)髓(sui)增生異常綜(zong)合征(zheng)、急性淋巴(ba)(ba)性白(bai)(bai)血(xue)(xue)(xue)(xue)(xue)病(bing)(all)、慢(man)性淋巴(ba)(ba)細(xi)(xi)胞(bao)性白(bai)(bai)血(xue)(xue)(xue)(xue)(xue)病(bing)(cll)、急性髓(sui)性白(bai)(bai)血(xue)(xue)(xue)(xue)(xue)病(bing)(aml)、慢(man)性髓(sui)細(xi)(xi)胞(bao)性白(bai)(bai)血(xue)(xue)(xue)(xue)(xue)病(bing)(cml)、原(yuan)始(shi)細(xi)(xi)胞(bao)危象慢(man)性髓(sui)細(xi)(xi)胞(bao)性白(bai)(bai)血(xue)(xue)(xue)(xue)(xue)病(bing)(bccml)、b細(xi)(xi)胞(bao)急性淋巴(ba)(ba)性白(bai)(bai)血(xue)(xue)(xue)(xue)(xue)病(bing)(b-all)、t細(xi)(xi)胞(bao)急性淋巴(ba)(ba)性白(bai)(bai)血(xue)(xue)(xue)(xue)(xue)病(bing)(t-all)、t細(xi)(xi)胞(bao)淋巴(ba)(ba)瘤和b細(xi)(xi)胞(bao)淋巴(ba)(ba)瘤。

82.根據權利要求80所述(shu)的方法，其中所述(shu)癌(ai)(ai)癥是選自由以下組(zu)成(cheng)的組(zu)的實體瘤(liu)：肺癌(ai)(ai)、乳腺(xian)癌(ai)(ai)、肝癌(ai)(ai)、胃癌(ai)(ai)、結(jie)腸(chang)癌(ai)(ai)、直(zhi)腸(chang)癌(ai)(ai)、結(jie)直(zhi)腸(chang)癌(ai)(ai)、腎(shen)癌(ai)(ai)、胃癌(ai)(ai)、膽囊癌(ai)(ai)、小腸(chang)癌(ai)(ai)、食管(guan)癌(ai)(ai)、黑(hei)色素瘤(liu)、骨(gu)癌(ai)(ai)、胰腺(xian)癌(ai)(ai)、皮膚癌(ai)(ai)、子宮癌(ai)(ai)、卵(luan)巢癌(ai)(ai)、睪丸(wan)癌(ai)(ai)、甲(jia)狀腺(xian)癌(ai)(ai)、腎(shen)上腺(xian)癌(ai)(ai)、膀胱癌(ai)(ai)和膠質瘤(liu)。

83.根據權利(li)要求68所述的(de)方(fang)法(fa)，其中(zhong)所述疾病(bing)(bing)是選自由以下組(zu)成的(de)組(zu)的(de)與(yu)腎(shen)(shen)(shen)(shen)(shen)相關的(de)疾病(bing)(bing)：感(gan)染后腎(shen)(shen)(shen)(shen)(shen)小球(qiu)(qiu)腎(shen)(shen)(shen)(shen)(shen)炎(yan)(yan)(yan)(yan)(yan)(yan)、iga腎(shen)(shen)(shen)(shen)(shen)病(bing)(bing)(伯格(ge)氏(shi)病(bing)(bing)(berger's?disease))、亨諾-許蘭紫癜(henoch-?purpura)、系統(tong)(tong)性(xing)(xing)(xing)iga血(xue)管炎(yan)(yan)(yan)(yan)(yan)(yan)、顯(xian)微(wei)(wei)鏡下多血(xue)管炎(yan)(yan)(yan)(yan)(yan)(yan)、肉(rou)芽(ya)(ya)腫性(xing)(xing)(xing)多血(xue)管炎(yan)(yan)(yan)(yan)(yan)(yan)(韋格(ge)納氏(shi)病(bing)(bing))、嗜酸性(xing)(xing)(xing)肉(rou)芽(ya)(ya)腫性(xing)(xing)(xing)多血(xue)管炎(yan)(yan)(yan)(yan)(yan)(yan)(查爾格(ge)-施特(te)勞斯綜合(he)征)、多動脈炎(yan)(yan)(yan)(yan)(yan)(yan)、特(te)發(fa)性(xing)(xing)(xing)新月體性(xing)(xing)(xing)腎(shen)(shen)(shen)(shen)(shen)小球(qiu)(qiu)腎(shen)(shen)(shen)(shen)(shen)炎(yan)(yan)(yan)(yan)(yan)(yan)、抗gbm腎(shen)(shen)(shen)(shen)(shen)小球(qiu)(qiu)腎(shen)(shen)(shen)(shen)(shen)炎(yan)(yan)(yan)(yan)(yan)(yan)、古德帕斯丘綜合(he)征、冷球(qiu)(qiu)蛋(dan)白相關腎(shen)(shen)(shen)(shen)(shen)小球(qiu)(qiu)腎(shen)(shen)(shen)(shen)(shen)炎(yan)(yan)(yan)(yan)(yan)(yan)、特(te)發(fa)性(xing)(xing)(xing)膜(mo)增殖性(xing)(xing)(xing)腎(shen)(shen)(shen)(shen)(shen)小球(qiu)(qiu)腎(shen)(shen)(shen)(shen)(shen)炎(yan)(yan)(yan)(yan)(yan)(yan)(mpgn)、丙型肝炎(yan)(yan)(yan)(yan)(yan)(yan)相關腎(shen)(shen)(shen)(shen)(shen)小球(qiu)(qiu)腎(shen)(shen)(shen)(shen)(shen)炎(yan)(yan)(yan)(yan)(yan)(yan)、系統(tong)(tong)性(xing)(xing)(xing)紅斑狼瘡(sle)相關腎(shen)(shen)(shen)(shen)(shen)小球(qiu)(qiu)腎(shen)(shen)(shen)(shen)(shen)炎(yan)(yan)(yan)(yan)(yan)(yan)、微(wei)(wei)小病(bing)(bing)變(bian)(無(wu)病(bing)(bing)、類脂性(xing)(xing)(xing)腎(shen)(shen)(shen)(shen)(shen)病(bing)(bing))、膜(mo)性(xing)(xing)(xing)腎(shen)(shen)(shen)(shen)(shen)病(bing)(bing)、局灶(zao)性(xing)(xing)(xing)和(he)節段(duan)性(xing)(xing)(xing)腎(shen)(shen)(shen)(shen)(shen)小球(qiu)(qiu)硬化(hua)、淀(dian)粉樣變(bian)性(xing)(xing)(xing)、糖尿病(bing)(bing)腎(shen)(shen)(shen)(shen)(shen)病(bing)(bing)、hiv相關腎(shen)(shen)(shen)(shen)(shen)病(bing)(bing)、膜(mo)性(xing)(xing)(xing)增殖性(xing)(xing)(xing)腎(shen)(shen)(shen)(shen)(shen)小球(qiu)(qiu)腎(shen)(shen)(shen)(shen)(shen)病(bing)(bing)、減輕的(de)蛋(dan)白尿、減輕的(de)慢(man)(man)性(xing)(xing)(xing)腎(shen)(shen)(shen)(shen)(shen)衰竭和(he)/或嚴重慢(man)(man)性(xing)(xing)(xing)腎(shen)(shen)(shen)(shen)(shen)病(bing)(bing)(ckd)/終末期腎(shen)(shen)(shen)(shen)(shen)病(bing)(bing)(esrd)的(de)死亡率/發(fa)病(bing)(bing)率降低。

84.根據(ju)權利要求68所(suo)述的方(fang)法，其中所(suo)述疾病(bing)(bing)是(shi)選自由以下組成的組的與(yu)胰(yi)(yi)腺(xian)相(xiang)關的疾病(bing)(bing)：高(gao)血(xue)糖(tang)、糖(tang)尿(niao)病(bing)(bing)前期、糖(tang)尿(niao)病(bing)(bing)(1型和/或2型)和胰(yi)(yi)腺(xian)炎。

85.根據權(quan)利要求68所(suo)述的(de)方法，其中所(suo)述疾病(bing)是選(xuan)自(zi)由(you)以(yi)下(xia)組成的(de)組的(de)與肝(gan)相關(guan)的(de)疾病(bing)：慢(man)性(xing)(xing)病(bing)毒(du)性(xing)(xing)肝(gan)炎、自(zi)身(shen)免疫性(xing)(xing)肝(gan)炎、酒精性(xing)(xing)肝(gan)病(bing)、非酒精性(xing)(xing)脂肪性(xing)(xing)肝(gan)病(bing)、血(xue)色素沉(chen)著癥(zheng)、威爾森(sen)氏病(bing)(wilson?disease)、原發性(xing)(xing)膽道炎、原發性(xing)(xing)硬化(hua)性(xing)(xing)膽管炎和膽石癥(zheng)。

86.根據(ju)權利要求68所述的方(fang)法，其中(zhong)所述疾病(bing)(bing)(bing)是選(xuan)自由以(yi)下組(zu)成的組(zu)的與腸(chang)相關(guan)的疾病(bing)(bing)(bing)：胃(wei)食管(guan)反流病(bing)(bing)(bing)(gerd)、胃(wei)炎、消化(hua)性潰(kui)瘍、肥胖、惡病(bing)(bing)(bing)質、腸(chang)絞痛、克羅恩(en)病(bing)(bing)(bing)(crohndisease)、潰(kui)瘍性結腸(chang)炎、抗生素相關(guan)結腸(chang)炎、腸(chang)易激綜合征(zheng)、結腸(chang)癌、結腸(chang)息(xi)肉(rou)病(bing)(bing)(bing)和(he)類癌。

87.根據權利要求(qiu)68所(suo)述(shu)的(de)(de)方法，其中所(suo)述(shu)疾病(bing)(bing)是選自由以下(xia)組成的(de)(de)組的(de)(de)與血(xue)(xue)細胞(bao)相(xiang)關的(de)(de)疾病(bing)(bing)：缺(que)鐵性(xing)(xing)貧血(xue)(xue)、慢性(xing)(xing)病(bing)(bing)性(xing)(xing)貧血(xue)(xue)、溶血(xue)(xue)性(xing)(xing)貧血(xue)(xue)、地(di)中海貧血(xue)(xue)、真(zhen)性(xing)(xing)紅細胞(bao)增多癥(zheng)、鐮(lian)狀(zhuang)細胞(bao)病(bing)(bing)貧血(xue)(xue)、鐮(lian)狀(zhuang)細胞(bao)病(bing)(bing)疼痛(tong)、免疫(yi)性(xing)(xing)血(xue)(xue)小板減少癥(zheng)、白血(xue)(xue)病(bing)(bing)、非(fei)霍奇(qi)金淋巴瘤(liu)(non-hodgkinlymphoma)和霍奇(qi)金淋巴瘤(liu)(hodgkinlymphoma)。

88.根(gen)據權利(li)要(yao)求68所(suo)述的方(fang)法，其中所(suo)述疾(ji)病是與氧(yang)化應(ying)激(ji)(ji)、谷胱甘肽(tai)(gsh)耗(hao)竭、nrf2激(ji)(ji)活和/或血紅素(su)加氧(yang)酶(mei)激(ji)(ji)活相關(guan)的疾(ji)病。

89.根據權利要求(qiu)88所(suo)述的方法，其中所(suo)述疾病是貧血、鐮狀細胞病和/或腎小球(qiu)腎炎(yan)。

90.根據權(quan)利要求88或89所述的方法(fa)，其中所述方法(fa)進(jin)一步包括向所述受試者施用n-乙(yi)酰半胱(guang)氨酸(nac)相關(guan)藥劑(ji)。

91.根據權利要求90所述(shu)的方法，其中所述(shu)nac相關藥劑選自由以下(xia)組(zu)成的組(zu)：胱(guang)氨酸、甲硫(liu)氨酸、n-乙酰半(ban)胱(guang)氨酸和l-2-氧代噻唑烷-4-甲酸酯。

92.根據權(quan)利要求(qiu)68所(suo)述的(de)方法，其中所(suo)述疾(ji)病是由吸(xi)入顆粒物質(zhi)誘導的(de)氧化應激(ji)、內(nei)皮功能障礙、動(dong)脈(mo)變窄和(he)/或增厚和(he)/或炎癥。

93.根據權利(li)要(yao)求68所述(shu)的(de)方法，其中所述(shu)疾病是由長期和(he)/或(huo)短(duan)期暴露于空氣污染誘導的(de)氧化應激、內皮功(gong)能障礙、動(dong)脈變窄(zhai)和(he)/或(huo)增厚和(he)/或(huo)炎(yan)癥。

94.根據權利要(yao)求(qiu)68至(zhi)93中(zhong)任(ren)一項所述(shu)(shu)(shu)(shu)的方法，其中(zhong)向所述(shu)(shu)(shu)(shu)受試者施用所述(shu)(shu)(shu)(shu)組合(he)物(wu)、所述(shu)(shu)(shu)(shu)試劑盒(he)或所述(shu)(shu)(shu)(shu)lr-etepa組合(he)物(wu)以(yi)提(ti)供約1g至(zhi)約20g的etepa的日劑量。

95.根據權利(li)要求94所(suo)述(shu)的(de)方法(fa)，其中(zhong)向所(suo)述(shu)受(shou)試(shi)者施(shi)用所(suo)述(shu)組(zu)合物、所(suo)述(shu)試(shi)劑盒或所(suo)述(shu)lr-etepa組(zu)合物以提供(gong)約4g的(de)etepa的(de)日(ri)劑量(liang)。

96.根(gen)據(ju)權利(li)要求68至95中(zhong)任一(yi)項所述(shu)(shu)的(de)方法，其中(zhong)將所述(shu)(shu)組合(he)物、所述(shu)(shu)試劑盒或所述(shu)(shu)lr-etepa組合(he)物每天一(yi)次(ci)或兩次(ci)施用于所述(shu)(shu)受(shou)試者。

97.根據權利(li)要求68至96中(zhong)任一項所(suo)述的方法，其中(zhong)在進(jin)食(shi)或未進(jin)食(shi)的情況下向所(suo)述受(shou)試者施用所(suo)述組(zu)合物、所(suo)述試劑盒或所(suo)述lr-etepa組(zu)合物。

98.根據權(quan)(quan)利(li)(li)要(yao)求(qiu)1至(zhi)32中(zhong)任(ren)一(yi)項所述的組合(he)物(wu)、根據權(quan)(quan)利(li)(li)要(yao)求(qiu)33至(zhi)52中(zhong)任(ren)一(yi)項所述的試(shi)劑盒或根據權(quan)(quan)利(li)(li)要(yao)求(qiu)53至(zhi)67中(zhong)任(ren)一(yi)項所述的lr-etepa組合(he)物(wu)，其(qi)在治療或預防有需要(yao)的受試(shi)者(zhe)的疾(ji)病的方(fang)法中(zhong)使(shi)用，其(qi)中(zhong)向所述受試(shi)者(zhe)施用治療有效量的所述組合(he)物(wu)、所述試(shi)劑盒或所述lr-etepa組合(he)物(wu)。

99.根據權利(li)要求98所述的組合(he)物、試劑盒或lr-etepa組合(he)物，其中所述疾病(bing)是心血(xue)管疾病(bing)。

100.根據權利(li)要(yao)求99所述(shu)的組合(he)物、試劑盒或lr-etepa組合(he)物，其中所述(shu)心(xin)血(xue)管(guan)(guan)疾(ji)病選自(zi)由以下組成(cheng)的組：高(gao)甘油(you)三(san)酯血(xue)癥(zheng)(zheng)、高(gao)膽固醇(chun)血(xue)癥(zheng)(zheng)、混合(he)性(xing)(xing)(xing)(xing)血(xue)脂異常、冠(guan)心(xin)病、中風、動(dong)脈(mo)(mo)粥樣硬化、心(xin)律失常、高(gao)血(xue)壓、心(xin)肌(ji)(ji)(ji)梗塞(sai)、血(xue)管(guan)(guan)炎、心(xin)肌(ji)(ji)(ji)病(例如，病毒(du)性(xing)(xing)(xing)(xing)心(xin)肌(ji)(ji)(ji)病，包含(han)與covid-19相關(guan)的病毒(du)性(xing)(xing)(xing)(xing)心(xin)肌(ji)(ji)(ji)病)、心(xin)包炎、充血(xue)性(xing)(xing)(xing)(xing)心(xin)力衰(shuai)竭、心(xin)肌(ji)(ji)(ji)壞死、血(xue)管(guan)(guan)缺(que)血(xue)、心(xin)肺系統外血(xue)管(guan)(guan)疾(ji)病、血(xue)栓性(xing)(xing)(xing)(xing)疾(ji)病、心(xin)肌(ji)(ji)(ji)梗塞(sai)后心(xin)臟重(zhong)構、巨細(xi)胞(bao)動(dong)脈(mo)(mo)炎、結節性(xing)(xing)(xing)(xing)多動(dong)脈(mo)(mo)炎、冷球蛋(dan)白血(xue)癥(zheng)(zheng)、發(fa)作性(xing)(xing)(xing)(xing)小血(xue)管(guan)(guan)缺(que)血(xue)(雷諾氏病)、深靜脈(mo)(mo)血(xue)栓形成(cheng)、彌散性(xing)(xing)(xing)(xing)血(xue)管(guan)(guan)內凝(ning)血(xue)和勃(bo)起功能障礙(ai)。

101.根(gen)據權利要求(qiu)99或100所述的(de)(de)組合物、試劑盒或lr-etepa組合物，其中所述受試者的(de)(de)空腹基線甘油三酯(zhi)水(shui)平為約(yue)(yue)135mg/dl至約(yue)(yue)500mg/dl。

102.根據(ju)權利(li)要求99至(zhi)101中(zhong)任一(yi)項所述的(de)(de)(de)組合物、試劑盒或lr-etepa組合物，其中(zhong)所述受試者具有以下中(zhong)的(de)(de)(de)一(yi)項或多(duo)項：約(yue)(yue)(yue)(yue)200mg/dl至(zhi)約(yue)(yue)(yue)(yue)300mg/dl的(de)(de)(de)基(ji)線(xian)非高密(mi)(mi)度脂(zhi)蛋白膽固(gu)醇(hdl-c)值(zhi)；約(yue)(yue)(yue)(yue)250mg/dl至(zhi)約(yue)(yue)(yue)(yue)300mg/dl的(de)(de)(de)基(ji)線(xian)總膽固(gu)醇(tc)值(zhi)；約(yue)(yue)(yue)(yue)140mg/dl至(zhi)約(yue)(yue)(yue)(yue)200mg/dl的(de)(de)(de)基(ji)線(xian)極低密(mi)(mi)度脂(zhi)蛋白膽固(gu)醇(vldl-c)值(zhi)；約(yue)(yue)(yue)(yue)10mg/dl至(zhi)約(yue)(yue)(yue)(yue)30mg/dl的(de)(de)(de)基(ji)線(xian)hdl-c值(zhi)；約(yue)(yue)(yue)(yue)40mg/dl至(zhi)約(yue)(yue)(yue)(yue)100mg/dl的(de)(de)(de)基(ji)線(xian)低密(mi)(mi)度脂(zhi)蛋白膽固(gu)醇(ldl-c)值(zhi)；以及約(yue)(yue)(yue)(yue)2mg/dl或更低的(de)(de)(de)基(ji)線(xian)高敏感c反應蛋白(hscrp)水平。

103.根(gen)據權(quan)利(li)要(yao)求99至102中任一項所述的(de)組合物(wu)、試劑(ji)盒(he)或lr-etepa組合物(wu)，其中所述受試者(zhe)正在進(jin)行穩定的(de)他汀類療法(fa)。

104.根據(ju)權利(li)要求103所述(shu)(shu)的組合物、試(shi)劑盒或lr-etepa組合物，其中所述(shu)(shu)穩(wen)定的他(ta)汀類療法包括(kuo)他(ta)汀類以及任選地依折麥布。

105.根據(ju)權利要(yao)求104所述(shu)的組合物、試劑盒(he)或lr-etepa組合物，其中所述(shu)他汀(ting)類選自由以下(xia)組成的組：阿托伐(fa)他汀(ting)、氟伐(fa)他汀(ting)、洛伐(fa)他汀(ting)、匹伐(fa)他汀(ting)、普伐(fa)他汀(ting)、瑞舒伐(fa)他汀(ting)和辛伐(fa)他汀(ting)。

106.根據權利要求(qiu)98所述的組合物、試劑(ji)盒或lr-etepa組合物，其中所述疾病是肺部(bu)疾病。

107.根(gen)據權利要求106所述(shu)的(de)組(zu)合物、試劑盒或lr-etepa組(zu)合物，其中所述(shu)肺(fei)(fei)部疾病(bing)選自由(you)以下組(zu)成的(de)組(zu)：社(she)區獲得性(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)炎(yan)(yan)(yan)(yan)(yan)(yan)、covid-19肺(fei)(fei)炎(yan)(yan)(yan)(yan)(yan)(yan)、全身性(xing)(xing)(xing)(xing)(xing)炎(yan)(yan)(yan)(yan)(yan)(yan)癥反應(ying)綜(zong)(zong)(zong)合征(zheng)(sirs)、敗血(xue)(xue)(xue)癥、sirs、急(ji)性(xing)(xing)(xing)(xing)(xing)呼(hu)吸窘迫綜(zong)(zong)(zong)合征(zheng)(ards)、肺(fei)(fei)栓塞、彌(mi)漫性(xing)(xing)(xing)(xing)(xing)間(jian)質性(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)炎(yan)(yan)(yan)(yan)(yan)(yan)、放射性(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)炎(yan)(yan)(yan)(yan)(yan)(yan)、胸膜炎(yan)(yan)(yan)(yan)(yan)(yan)、急(ji)性(xing)(xing)(xing)(xing)(xing)嗜(shi)酸(suan)性(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)炎(yan)(yan)(yan)(yan)(yan)(yan)、慢性(xing)(xing)(xing)(xing)(xing)嗜(shi)酸(suan)性(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)炎(yan)(yan)(yan)(yan)(yan)(yan)、呂(lv)弗勒綜(zong)(zong)(zong)合征(zheng)、結節病(bing)、間(jian)質性(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)病(bing)、慢性(xing)(xing)(xing)(xing)(xing)阻(zu)塞性(xing)(xing)(xing)(xing)(xing)肺(fei)(fei)部疾病(bing)(copd)、反應(ying)性(xing)(xing)(xing)(xing)(xing)氣道疾病(bing)、哮喘、支(zhi)氣管擴(kuo)張(zhang)、細支(zhi)氣管炎(yan)(yan)(yan)(yan)(yan)(yan)、囊性(xing)(xing)(xing)(xing)(xing)纖維化、支(zhi)氣管類(lei)癌、肺(fei)(fei)動脈高(gao)壓、肺(fei)(fei)血(xue)(xue)(xue)管炎(yan)(yan)(yan)(yan)(yan)(yan)、顯微多血(xue)(xue)(xue)管炎(yan)(yan)(yan)(yan)(yan)(yan)、肉(rou)芽(ya)腫(zhong)性(xing)(xing)(xing)(xing)(xing)多血(xue)(xue)(xue)管炎(yan)(yan)(yan)(yan)(yan)(yan)(韋格(ge)納氏病(bing))、嗜(shi)酸(suan)性(xing)(xing)(xing)(xing)(xing)肉(rou)芽(ya)腫(zhong)性(xing)(xing)(xing)(xing)(xing)多血(xue)(xue)(xue)管炎(yan)(yan)(yan)(yan)(yan)(yan)(查爾格(ge)-施特勞斯綜(zong)(zong)(zong)合征(zheng))、鼻咽(yan)炎(yan)(yan)(yan)(yan)(yan)(yan)、古德帕斯丘氏綜(zong)(zong)(zong)合征(zheng)、冷(leng)球蛋白血(xue)(xue)(xue)癥、系(xi)(xi)統性(xing)(xing)(xing)(xing)(xing)紅斑狼(lang)瘡(chuang)(sle)、系(xi)(xi)統性(xing)(xing)(xing)(xing)(xing)硬化癥和(he)抗磷脂(zhi)綜(zong)(zong)(zong)合征(zheng)。

108.根據權利要求(qiu)98所述的組合物、試(shi)劑盒或lr-etepa組合物，其中所述疾病(bing)是神(shen)經系統疾病(bing)。

109.根據(ju)權(quan)利(li)要(yao)求108所述(shu)的組合物、試劑盒或lr-etepa組合物，其中所述(shu)神(shen)經系統疾病(bing)(bing)選自(zi)由以下組成(cheng)的組：亨廷頓氏(shi)(shi)病(bing)(bing)、睡眠障(zhang)礙(ai)(ai)、癡(chi)呆、精(jing)神(shen)病(bing)(bing)、焦慮癥、難治(zhi)性(xing)抑郁癥、神(shen)經性(xing)疼(teng)痛、精(jing)神(shen)分裂癥、雙相情感障(zhang)礙(ai)(ai)、閱讀障(zhang)礙(ai)(ai)、運(yun)動障(zhang)礙(ai)(ai)、注意力缺(que)(que)陷多動障(zhang)礙(ai)(ai)(adhd)、癲癇、自(zi)閉癥、阿爾茨海默氏(shi)(shi)病(bing)(bing)、帕(pa)金森氏(shi)(shi)病(bing)(bing)、老年性(xing)癡(chi)呆、多發性(xing)硬化癥、糖尿病(bing)(bing)誘導的神(shen)經病(bing)(bing)變(bian)、黃斑變(bian)性(xing)、早產兒視網(wang)膜(mo)病(bing)(bing)變(bian)、肌(ji)萎縮性(xing)側索硬化癥(als)、視網(wang)膜(mo)色(se)素變(bian)性(xing)癥、腦癱、肌(ji)肉萎縮癥、神(shen)經系統癌癥、囊性(xing)纖維化和神(shen)經管缺(que)(que)陷。

110.根據權利要求98所(suo)(suo)述的(de)組合物、試(shi)劑盒或lr-etepa組合物，其中所(suo)(suo)述疾病是(shi)癌癥。

111.根據權利要求110所(suo)述的組(zu)合(he)物、試劑盒或lr-etepa組(zu)合(he)物，其中所(suo)述癌(ai)癥是選(xuan)自由以下(xia)組(zu)成的組(zu)的血(xue)(xue)液系統惡性(xing)(xing)病：單克隆b細(xi)胞(bao)(bao)淋巴細(xi)胞(bao)(bao)增(zeng)(zeng)多癥、多發性(xing)(xing)骨髓(sui)(sui)(sui)瘤、髓(sui)(sui)(sui)系贅(zhui)生物、骨髓(sui)(sui)(sui)增(zeng)(zeng)生異常綜合(he)征(mds)、骨髓(sui)(sui)(sui)增(zeng)(zeng)殖/骨髓(sui)(sui)(sui)增(zeng)(zeng)生異常綜合(he)征、急(ji)性(xing)(xing)淋巴性(xing)(xing)白(bai)血(xue)(xue)病(all)、慢性(xing)(xing)淋巴細(xi)胞(bao)(bao)性(xing)(xing)白(bai)血(xue)(xue)病(cll)、急(ji)性(xing)(xing)髓(sui)(sui)(sui)性(xing)(xing)白(bai)血(xue)(xue)病(aml)、慢性(xing)(xing)髓(sui)(sui)(sui)細(xi)胞(bao)(bao)性(xing)(xing)白(bai)血(xue)(xue)病(cml)、原始細(xi)胞(bao)(bao)危象慢性(xing)(xing)髓(sui)(sui)(sui)細(xi)胞(bao)(bao)性(xing)(xing)白(bai)血(xue)(xue)病(bccml)、b細(xi)胞(bao)(bao)急(ji)性(xing)(xing)淋巴性(xing)(xing)白(bai)血(xue)(xue)病(b-all)、t細(xi)胞(bao)(bao)急(ji)性(xing)(xing)淋巴性(xing)(xing)白(bai)血(xue)(xue)病(t-all)、t細(xi)胞(bao)(bao)淋巴瘤和b細(xi)胞(bao)(bao)淋巴瘤。

112.根據權利(li)要求110所述的(de)組(zu)合物、試劑(ji)盒或lr-etepa組(zu)合物，其中所述癌(ai)(ai)(ai)癥(zheng)是選自由以下組(zu)成的(de)組(zu)的(de)實(shi)體(ti)瘤(liu)：肺癌(ai)(ai)(ai)、乳腺癌(ai)(ai)(ai)、肝癌(ai)(ai)(ai)、胃癌(ai)(ai)(ai)、結腸癌(ai)(ai)(ai)、直腸癌(ai)(ai)(ai)、結直腸癌(ai)(ai)(ai)、腎癌(ai)(ai)(ai)、胃癌(ai)(ai)(ai)、膽囊癌(ai)(ai)(ai)、小腸癌(ai)(ai)(ai)、食管癌(ai)(ai)(ai)、黑(hei)色(se)素瘤(liu)、骨癌(ai)(ai)(ai)、胰腺癌(ai)(ai)(ai)、皮膚癌(ai)(ai)(ai)、子宮癌(ai)(ai)(ai)、卵巢癌(ai)(ai)(ai)、睪(gao)丸癌(ai)(ai)(ai)、甲狀腺癌(ai)(ai)(ai)、腎上腺癌(ai)(ai)(ai)、膀(bang)胱癌(ai)(ai)(ai)和(he)膠(jiao)質瘤(liu)。

113.根據權利(li)要求98所述(shu)的組合物(wu)、試(shi)劑盒或(huo)lr-etepa組合物(wu)，其中所述(shu)疾病(bing)(bing)(bing)(bing)(bing)(bing)是(shi)選自由(you)以下組成的組的與(yu)腎(shen)(shen)(shen)相(xiang)關的疾病(bing)(bing)(bing)(bing)(bing)(bing)：感染后腎(shen)(shen)(shen)小(xiao)(xiao)(xiao)(xiao)球(qiu)(qiu)腎(shen)(shen)(shen)炎(yan)、iga腎(shen)(shen)(shen)病(bing)(bing)(bing)(bing)(bing)(bing)(伯(bo)格氏病(bing)(bing)(bing)(bing)(bing)(bing))、亨諾-許蘭紫癜、系統性(xing)(xing)(xing)(xing)iga血(xue)(xue)管炎(yan)、顯(xian)微(wei)(wei)鏡下多(duo)(duo)血(xue)(xue)管炎(yan)、肉芽腫(zhong)性(xing)(xing)(xing)(xing)多(duo)(duo)血(xue)(xue)管炎(yan)(韋格納氏病(bing)(bing)(bing)(bing)(bing)(bing))、嗜酸(suan)性(xing)(xing)(xing)(xing)肉芽腫(zhong)性(xing)(xing)(xing)(xing)多(duo)(duo)血(xue)(xue)管炎(yan)(查爾格-施特(te)勞斯綜合征)、多(duo)(duo)動(dong)脈(mo)炎(yan)、特(te)發性(xing)(xing)(xing)(xing)新(xin)月體性(xing)(xing)(xing)(xing)腎(shen)(shen)(shen)小(xiao)(xiao)(xiao)(xiao)球(qiu)(qiu)腎(shen)(shen)(shen)炎(yan)、抗(kang)gbm腎(shen)(shen)(shen)小(xiao)(xiao)(xiao)(xiao)球(qiu)(qiu)腎(shen)(shen)(shen)炎(yan)、古德帕(pa)斯丘綜合征、冷球(qiu)(qiu)蛋白相(xiang)關腎(shen)(shen)(shen)小(xiao)(xiao)(xiao)(xiao)球(qiu)(qiu)腎(shen)(shen)(shen)炎(yan)、特(te)發性(xing)(xing)(xing)(xing)膜(mo)增(zeng)殖性(xing)(xing)(xing)(xing)腎(shen)(shen)(shen)小(xiao)(xiao)(xiao)(xiao)球(qiu)(qiu)腎(shen)(shen)(shen)炎(yan)(mpgn)、丙型肝炎(yan)相(xiang)關腎(shen)(shen)(shen)小(xiao)(xiao)(xiao)(xiao)球(qiu)(qiu)腎(shen)(shen)(shen)炎(yan)、系統性(xing)(xing)(xing)(xing)紅斑(ban)狼瘡(sle)相(xiang)關腎(shen)(shen)(shen)小(xiao)(xiao)(xiao)(xiao)球(qiu)(qiu)腎(shen)(shen)(shen)炎(yan)、微(wei)(wei)小(xiao)(xiao)(xiao)(xiao)病(bing)(bing)(bing)(bing)(bing)(bing)變(無病(bing)(bing)(bing)(bing)(bing)(bing)、類脂性(xing)(xing)(xing)(xing)腎(shen)(shen)(shen)病(bing)(bing)(bing)(bing)(bing)(bing))、膜(mo)性(xing)(xing)(xing)(xing)腎(shen)(shen)(shen)病(bing)(bing)(bing)(bing)(bing)(bing)、局灶性(xing)(xing)(xing)(xing)和(he)節(jie)段(duan)性(xing)(xing)(xing)(xing)腎(shen)(shen)(shen)小(xiao)(xiao)(xiao)(xiao)球(qiu)(qiu)硬(ying)化、淀(dian)粉(fen)樣變性(xing)(xing)(xing)(xing)、糖尿病(bing)(bing)(bing)(bing)(bing)(bing)腎(shen)(shen)(shen)病(bing)(bing)(bing)(bing)(bing)(bing)、hiv相(xiang)關腎(shen)(shen)(shen)病(bing)(bing)(bing)(bing)(bing)(bing)、膜(mo)性(xing)(xing)(xing)(xing)增(zeng)殖性(xing)(xing)(xing)(xing)腎(shen)(shen)(shen)小(xiao)(xiao)(xiao)(xiao)球(qiu)(qiu)腎(shen)(shen)(shen)病(bing)(bing)(bing)(bing)(bing)(bing)、減輕(qing)(qing)的蛋白尿、減輕(qing)(qing)的慢(man)性(xing)(xing)(xing)(xing)腎(shen)(shen)(shen)衰(shuai)竭和(he)/或(huo)嚴重慢(man)性(xing)(xing)(xing)(xing)腎(shen)(shen)(shen)病(bing)(bing)(bing)(bing)(bing)(bing)(ckd)/終末(mo)期腎(shen)(shen)(shen)病(bing)(bing)(bing)(bing)(bing)(bing)(esrd)的死(si)亡率(lv)/發病(bing)(bing)(bing)(bing)(bing)(bing)率(lv)降(jiang)低。

114.根據權利要(yao)求98所述的組(zu)(zu)(zu)合物(wu)、試劑盒或lr-etepa組(zu)(zu)(zu)合物(wu)，其(qi)中(zhong)所述疾(ji)(ji)病是選自由以下組(zu)(zu)(zu)成(cheng)的組(zu)(zu)(zu)的與(yu)胰腺相關的疾(ji)(ji)病：高(gao)血糖(tang)、糖(tang)尿(niao)病前期、糖(tang)尿(niao)病(1型和(he)(he)/或2型)和(he)(he)胰腺炎(yan)。

115.根據權利要求(qiu)98所述的(de)組(zu)合物、試劑盒或lr-etepa組(zu)合物，其中(zhong)所述疾病(bing)是選自(zi)由以下組(zu)成的(de)組(zu)的(de)與(yu)肝(gan)相關的(de)疾病(bing)：慢性(xing)(xing)(xing)病(bing)毒性(xing)(xing)(xing)肝(gan)炎(yan)、自(zi)身免疫性(xing)(xing)(xing)肝(gan)炎(yan)、酒(jiu)精性(xing)(xing)(xing)肝(gan)病(bing)、非酒(jiu)精性(xing)(xing)(xing)脂肪性(xing)(xing)(xing)肝(gan)病(bing)、血色素(su)沉(chen)著癥、威(wei)爾森氏(shi)病(bing)、原發(fa)性(xing)(xing)(xing)膽道炎(yan)、原發(fa)性(xing)(xing)(xing)硬化性(xing)(xing)(xing)膽管炎(yan)和膽石癥。

116.根據權利要求98所述的組(zu)合(he)物、試劑盒或lr-etepa組(zu)合(he)物，其中(zhong)所述疾病(bing)是選自由以(yi)下組(zu)成的組(zu)的與腸(chang)(chang)相(xiang)關的疾病(bing)：胃食(shi)管反(fan)流病(bing)(gerd)、胃炎、消化性潰瘍、肥胖、惡病(bing)質、腸(chang)(chang)絞痛、克(ke)羅恩病(bing)、潰瘍性結(jie)腸(chang)(chang)炎、抗生(sheng)素相(xiang)關結(jie)腸(chang)(chang)炎、腸(chang)(chang)易激綜合(he)征、結(jie)腸(chang)(chang)癌、結(jie)腸(chang)(chang)息肉病(bing)和類(lei)癌。

117.根據(ju)權(quan)利要求98所(suo)述的(de)組(zu)合物、試劑盒或(huo)lr-etepa組(zu)合物，其(qi)中所(suo)述疾病(bing)是選自由以下組(zu)成(cheng)的(de)組(zu)的(de)與(yu)血(xue)(xue)細胞(bao)相關的(de)疾病(bing)：缺鐵性(xing)貧(pin)血(xue)(xue)、慢性(xing)病(bing)性(xing)貧(pin)血(xue)(xue)、溶血(xue)(xue)性(xing)貧(pin)血(xue)(xue)、地中海貧(pin)血(xue)(xue)、真(zhen)性(xing)紅(hong)細胞(bao)增多癥(zheng)(zheng)、鐮狀細胞(bao)病(bing)貧(pin)血(xue)(xue)、鐮狀細胞(bao)病(bing)疼痛、免疫性(xing)血(xue)(xue)小板(ban)減少癥(zheng)(zheng)、白血(xue)(xue)病(bing)、非(fei)霍(huo)奇金(jin)淋巴瘤(liu)和(he)霍(huo)奇金(jin)淋巴瘤(liu)。

118.根據權利(li)要求98所述的組(zu)合(he)物、試劑盒(he)或(huo)lr-etepa組(zu)合(he)物，其中所述疾病是與氧化應激、谷(gu)胱(guang)甘肽(tai)(gsh)耗竭、nrf2激活和/或(huo)血紅素加氧酶激活相(xiang)關(guan)的疾病。

119.根據權利要求(qiu)118所(suo)述的(de)組(zu)合物、試劑(ji)盒或lr-etepa組(zu)合物，其(qi)中所(suo)述疾病是貧血、鐮(lian)狀細胞(bao)病和/或腎小球腎炎。

120.根據權利要(yao)求118或119所述(shu)的組合(he)物、試(shi)劑(ji)盒或lr-etepa組合(he)物，其中(zhong)所述(shu)方(fang)法進(jin)一步包括向所述(shu)受試(shi)者施用n-乙酰半(ban)胱(guang)氨酸(nac)相關藥劑(ji)。

121.根據權(quan)利要求120所(suo)(suo)述的組(zu)(zu)合物、試(shi)劑(ji)盒或lr-etepa組(zu)(zu)合物，其中所(suo)(suo)述nac相關(guan)藥劑(ji)選(xuan)自由以下組(zu)(zu)成的組(zu)(zu)：胱氨酸、甲硫氨酸、n-乙酰半(ban)胱氨酸和l-2-氧代噻唑烷-4-甲酸酯。

122.根據權(quan)利要求98所(suo)述的(de)組合物、試(shi)劑盒或lr-etepa組合物，其中(zhong)所(suo)述疾病(bing)是由(you)吸入顆粒(li)物質誘導的(de)氧化(hua)應激、內皮功能(neng)障(zhang)礙、動(dong)脈(mo)變窄和/或增厚和/或炎癥(zheng)。

123.根據(ju)權利(li)要求98所述的組(zu)合物、試劑(ji)盒或lr-etepa組(zu)合物，其中所述疾病是由長期(qi)和/或短期(qi)暴露于空(kong)氣(qi)污染誘(you)導的氧(yang)化應(ying)激(ji)、內皮功能(neng)障礙、動(dong)脈變(bian)窄和/或增厚和/或炎(yan)癥。

124.根據權利要求98至123中任一項所(suo)述(shu)的組(zu)合物(wu)(wu)、試劑盒或lr-etepa組(zu)合物(wu)(wu)，其中向所(suo)述(shu)受(shou)試者(zhe)施用所(suo)述(shu)組(zu)合物(wu)(wu)、所(suo)述(shu)試劑盒或所(suo)述(shu)lr-etepa組(zu)合物(wu)(wu)以提供約1g至約20g的etepa的日劑量(liang)。

125.根(gen)據權利要求124所(suo)(suo)述(shu)的組合(he)物(wu)(wu)、試劑盒(he)或(huo)lr-etepa組合(he)物(wu)(wu)，其中(zhong)向所(suo)(suo)述(shu)受試者(zhe)施用所(suo)(suo)述(shu)組合(he)物(wu)(wu)、所(suo)(suo)述(shu)試劑盒(he)或(huo)所(suo)(suo)述(shu)lr-etepa組合(he)物(wu)(wu)以(yi)提供約4g的etepa的日劑量(liang)。

126.根據權利要求98至125中任(ren)一(yi)項所述(shu)(shu)(shu)的組(zu)合物(wu)(wu)、試劑(ji)(ji)盒或(huo)lr-etepa組(zu)合物(wu)(wu)，其中將所述(shu)(shu)(shu)組(zu)合物(wu)(wu)、所述(shu)(shu)(shu)試劑(ji)(ji)盒或(huo)所述(shu)(shu)(shu)lr-etepa組(zu)合物(wu)(wu)每天一(yi)次或(huo)兩次施用于所述(shu)(shu)(shu)受試者。

127.根據權利要求(qiu)98至126中任一項(xiang)所(suo)述(shu)的組(zu)合物、試(shi)劑(ji)盒或lr-etepa組(zu)合物，其中在(zai)進食或未進食的情況下向所(suo)述(shu)受試(shi)者施(shi)用所(suo)述(shu)組(zu)合物、所(suo)述(shu)試(shi)劑(ji)盒或所(suo)述(shu)lr-etepa組(zu)合物。

技術總結
提供了組合物以及使用其治療各種疾病的方法，所述組合物包括一種或多種多元不飽和脂肪酸或其衍生物、磷脂來源以及任選地一種或多種另外的乳化劑。在一些實施例中，提供了一種淋巴釋放的二十碳五烯酸乙基酯組合物(LR?EtEPA)以及使用其增加組織中的EPA攝取并治療各種疾病，包含心肺疾病、腎病、神經系統疾病和癌癥的方法。

技術研發人員：R·P·馬森,R·L·鄧巴
受保護的技術使用者：阿馬里納藥物愛爾蘭有限公司
技術研發日：
技術公布日：2024/9/29